US3950338A
Expired / Lapsed
US
⏱️ 0.0 years remaining
8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids and their preparation
Assignee: Laboratoire Roger Bellon SA
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Filing: 1973-07-31
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Granted: 1976-04-13
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Expires: 1993-07-31
Abstract
Abstract Valuable antibacterial 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids, some of which are new compounds, are made from corresponding pyrimidines by a process involving condensation with an amino-ester, cyclization, halogenation, dehydrohalogenation, and saponification.
Inventors
- 👤 Marcel Pesson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 05:09
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61P; A61P31/00; A61P31/04; C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
60 words
An 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)-pyrimidine-6-carboxylic acid of the formula: ##SPC24## wherein: - R' is lower alkyl radical and R is of formula ##SPC25## in which n is 0, 1, 2, or 3, and R 3 is hydrogen, hydroxyl, vinyl, phenyl or phenyl substituted by halogen or lower alkoxy, the term "lower alkyl, lower alkoxy" meaning a radical with 1 to 5 carbon atoms.
Claim 2
Dependent Claim
60 words
An 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)-pyrimidine-6-carboxylic acid of the formula: ##SPC24## wherein: - R' is lower alkyl radical and R is of formula ##SPC25## in which n is 0, 1, 2, or 3, and R 3 is hydrogen, hydroxyl, vinyl, phenyl or phenyl substituted by halogen or lower alkoxy, the term "lower alkyl, lower alkoxy" meaning a radical with 1 to 5 carbon atoms.
Claim 3
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4-methyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid.
Claim 4
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-piperazino-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)-pyrimidine-6-carboxylic acid.
Claim 5
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-β-hydroxyethyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)-pyrimidine-6-carboxylic acid.
Claim 6
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-benzyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido-(2,3-d)-pyrimidine-6-carboxylic acid.
Claim 7
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-4'-methyl-piperazino)-5-oxo-8-methyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine-6-carboxylic acid.
Claim 8
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-β-hydroxyethyl-piperazino)-5-oxo-8-methyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid.
Claim 9
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-ethyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine-6-carboxylic acid.
Claim 10
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-propyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine-6-carboxylic acid.
Claim 11
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-allyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine-6-carboxylic acid.
Claim 12
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-p-chlorobenzyl-piperazino)-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid.
Claim 13
Dependent Claim
11 words
An acid as claimed in claim 1 which is 2-(4'-p-methoxybenzyl-piperazino-5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid.
References Cited (Backward Citations)
US3770742A
Cited
US3673184A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-13 | 1979-10-13 | 1980-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-13 | 1983-10-13 | 1984-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-13 | 1987-10-13 | 1988-04-13 | $7700.00 | Window Closed / Lapsed |