US3954764A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dibenzo [b,f]thiepins bearing piperazinyl substitution
Assignee: Hoffmann La Roche Inc
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Filing: 1974-05-17
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Granted: 1976-05-04
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Expires: 1994-05-17
Abstract
Abstract Compounds of the formulas WHEREIN R1, R2, R3, R4, R5, R6, m and n and X are as hereinafter set forth, ARE DESCRIBED. The compounds of formulas I and Ia are useful as neuroleptic agents.
Inventors
- 👤 Max Gerecke
- 👤 Jean-Pierre Kaplan
- 👤 Emilio Kyburz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:00
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/14
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
84 words
A compound of the formula ##SPC17## wherein one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, chloro, fluoro or trifluoromethyl; one of R 3 and R 4 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, chloro, fluoro or trifluoromethyl; n is 2 or 3; m is 0; X is oxygen, and R 5 and R 6 are hydrogen or taken together are the group ##SPC18## or a salt thereof with a pharmaceutically acceptable acid.
Claim 2
Dependent Claim
84 words
A compound of the formula ##SPC17## wherein one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, chloro, fluoro or trifluoromethyl; one of R 3 and R 4 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, chloro, fluoro or trifluoromethyl; n is 2 or 3; m is 0; X is oxygen, and R 5 and R 6 are hydrogen or taken together are the group ##SPC18## or a salt thereof with a pharmaceutically acceptable acid.
Claim 3
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 2 and R 3 are hydrogen; R 1 is methyl and R 4 is chloro.
Claim 4
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 2 and R 4 are hydrogen; R 1 is chloro and R 3 is fluoro.
Claim 5
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 1 and R 3 are hydrogen; R 2 is methoxy and R 4 is methylthio.
Claim 6
Dependent Claim
19 words
A compound in accordance with claim 1, wherein n is 2; and R 5 and R 6 are hydrogen.
Claim 7
Dependent Claim
19 words
A compound in accordance with claim 2, wherein n is 2; and R 5 and R 6 are hydrogen.
Claim 8
Dependent Claim
19 words
A compound in accordance with claim 3, wherein n is 2; and R 5 and R 6 are hydrogen.
Claim 9
Dependent Claim
19 words
A compound in accordance with claim 4, wherein n is 2; and R 5 and R 6 are hydrogen.
Claim 10
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 2 and R 3 are hydrogen, R 1 is methyl and R 4 is fluoro.
Claim 11
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 2 and R 3 are hydrogen, R 1 is methyl and R 4 is methylthio.
Claim 12
Dependent Claim
24 words
A compound in accordance with claim 1, wherein R 2 and R 3 are hydrogen, R 1 is chloro and R 4 is fluoro.
Claim 13
Dependent Claim
8 words
A compound in accordance with claim 1, 3-{2-[4-(8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl}-2-oxazolidinone.
Claim 14
Dependent Claim
8 words
A compound in accordance with claim 1, 3-{2-[4-(2-chloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl}-2-oxazolidinone.
Claim 15
Dependent Claim
9 words
A compound in accordance with claim 1, 3-{2-[4-( 10,11-dihydro-2-methyl-8-(methylthio)-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl}-2-oxazolidinone.
Claim 16
Dependent Claim
8 words
A compound in accordance with claim 1, 3-{2-[4-(2-chloro-7-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl}-2-oxazolidinone.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-04 | 1979-11-03 | 1980-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-04 | 1983-11-03 | 1984-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-04 | 1987-11-03 | 1988-05-04 | $7700.00 | Window Closed / Lapsed |