US3956260A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypocalcaemic peptides and processes for their manufacture
Assignee: Novartis Corp
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Filing: 1971-12-10
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Granted: 1976-05-11
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Expires: 1991-12-10
Abstract
Abstract Synthetic hypocalcaemic dotriacontapeptide of the formula H-Cys-Ser-Asn-Leu-Ser--Thr-Cys-Val-Leu-Ser-Ala-Tyr-Try-Arg-Asn-Leu-Asn-Asn-Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-OH I and analogues and derivatives, salts and complexes thereof and process for their manufacture.
Inventors
- 👤 Max Brugger
- 👤 Friedrich Werner Kahnt
- 👤 Bruno Kamber
- 👤 Robert Neher
- 👤 Bernhard Riniker
- 👤 Werner Rittel
- 👤 Peter Sieber
- 👤 Herbert Zuber
- 👤 Hendrik Marie Greven
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:53
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/08; C07K1/00; C07K1/06; C07K1/061; C07K1/067; C07K14/00; C07K14/435; C07K14/575; C07K14/585; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07K5/06034; C07K5/06052; C07K5/0606; C07K5/06069; C07K5/06104; C07K5/06113; C07K5/08; C07K5/0802; C07K5/0804; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1016; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
83 words
A peptide of the formula I H-L-Cys-L-Ser-L-X-L-Leu-L-Ser-L-Thr-L-Cys-L-Val-L-Leu-L-Ser-L-Ala-L-Tyr-L-Arg-L-X-Leu-L-X-L-X-L-Phe-L-His-L-Arg-L-Phe-L-Ser-Gly-L-Z-Gly-L-Phe-Gly-L-Pro-L-Y-L-Thr-L-Pro-NH 2 in which X is a member selected from the group consisting of aspartyl and asparaginyl, Y is a member selected from the group consisting of glutamyl and glutaminyl and Z is a member selected from the group consisting of methionyl, valyl, norvalyl, leucyl, isoleucyl, and norleucyl, a Met 25 -sulfoxide, N.sup.α-acyl derivative or N.sup.α-desamino derivative thereof with the exception of H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Ser-Ala-Tyr-Try-Arg-Asn-Leu-Asn-Asn-Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-NH 2 and its Met 25 -sulfoxide, or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
83 words
A peptide of the formula I H-L-Cys-L-Ser-L-X-L-Leu-L-Ser-L-Thr-L-Cys-L-Val-L-Leu-L-Ser-L-Ala-L-Tyr-L-Arg-L-X-Leu-L-X-L-X-L-Phe-L-His-L-Arg-L-Phe-L-Ser-Gly-L-Z-Gly-L-Phe-Gly-L-Pro-L-Y-L-Thr-L-Pro-NH 2 in which X is a member selected from the group consisting of aspartyl and asparaginyl, Y is a member selected from the group consisting of glutamyl and glutaminyl and Z is a member selected from the group consisting of methionyl, valyl, norvalyl, leucyl, isoleucyl, and norleucyl, a Met 25 -sulfoxide, N.sup.α-acyl derivative or N.sup.α-desamino derivative thereof with the exception of H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Ser-Ala-Tyr-Try-Arg-Asn-Leu-Asn-Asn-Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-NH 2 and its Met 25 -sulfoxide, or a therapeutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-11 | 1979-11-10 | 1980-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-11 | 1983-11-10 | 1984-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-11 | 1987-11-10 | 1988-05-11 | $7700.00 | Window Closed / Lapsed |