US3962438A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
Assignee: GlaxoSmithKline LLC
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Filing: 1975-01-07
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Granted: 1976-06-08
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Expires: 1995-01-07
Abstract
Abstract 1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents.
Inventors
- 👤 Charles E. Berkoff
- 👤 Blaine M. Sutton
- 👤 Joseph Weinstock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 02:43
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/06; C07D279/00; C07D279/10; C07D279/14; C07D279/18
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
44 words
A compound of the formula: ##SPC4## in which: X is S, SO or SO 2 ; Y is O or S; R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl or nitro; and R 2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, dihydroxy(lower)alkyl or phenyl(lower)alkyl.
Claim 2
Dependent Claim
44 words
A compound of the formula: ##SPC4## in which: X is S, SO or SO 2 ; Y is O or S; R 1 is hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl or nitro; and R 2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, dihydroxy(lower)alkyl or phenyl(lower)alkyl.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 in which Y is S.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 in which Y is O.
Claim 5
Dependent Claim
23 words
A compound according to claim 3 in which R 1 is in the 10-position and R 2 is hydrogen, lower alkyl or hydroxy(lower)alkyl.
Claim 6
Dependent Claim
23 words
A compound according to claim 4 in which R 1 is trifluoromethyl in the 10-position and X is SO or SO 2 .
Claim 7
Dependent Claim
10 words
A compound according to claim 5, said compound being 2-(2-hydroxyethyl)-10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione-7-oxide.
Claim 8
Dependent Claim
10 words
A compound according to claim 5, said compound being 2-(2-hydroxyethyl)-10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione-7,7-dioxide.
Claim 9
Dependent Claim
10 words
A compound according to claim 5, said compound being 2-ethyl-10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-dione-7-oxide.
Claim 10
Dependent Claim
10 words
A compound according to claim 5, said compound being 10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine1,3(2H)-dione-7,7-dioxide.
Claim 11
Dependent Claim
10 words
A compound according to claim 5, said compound being 10-trifluoromethyl-1H-pyrimido[5,4,3-kl]phenothiazine1,3(2H)-dione-7-oxide
Claim 12
Dependent Claim
28 words
A pharmaceutical composition having antiarthritic activity, in dosage unit form, comprising a pharmaceutical carrier and an effective but nontoxic amount of a compound as claimed in claim 1.
Claim 13
Dependent Claim
27 words
A method of treating arthritis which comprises administering internally to an animal subject an amount of a compound as claimed in claim 1 sufficient to inhibit arthritis.
References Cited (Backward Citations)
US3493567A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-08 | 1979-12-08 | 1980-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-08 | 1983-12-08 | 1984-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-08 | 1987-12-08 | 1988-06-08 | $7700.00 | Window Closed / Lapsed |