US3963701A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted benzhydryl lactamimide derivatives
Assignee: Richardson Vicks Inc
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Filing: 1973-08-27
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Granted: 1976-06-15
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Expires: 1993-08-27
Abstract
Abstract Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula ##SPC1## Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R 1 may be the same or different and represent hydrogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, halogen, trifluorometyl, trifluoromethylthio, trifluoromethoxy, phenyl, phenoxy, or lower alkoxy of from 1 to 4 carbon atoms, with the proviso that both R and R' are not hydrogen, and with the proviso that when m is equal to 1, and one of R or R 1 is hydrogen the other of R or R 1 is not lower alkoxy of from 1 to 4 carbon atoms; and pharmaceutically acceptable acid addition salts and individual optical isomers where applicable.
Inventors
- 👤 Johann Martin Grisar
- 👤 Norbert Leonard Wiech
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:37
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/68; C07D211/72; C07D223/00; C07D223/02; C07D223/06; C07D223/12; C07D225/00; C07D225/02; C07D227/00; C07D227/02; C07D227/06; C07D227/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
137 words
A compound selected from a base of the formula ##SPC11## wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; each of R and R 1 is selected from the group consisting of hydrogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a halogen atom, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, phenyl, phenoxy, a lower alkoxy group of from 1 to 4 carbon atoms, with the proviso that both R and R 1 are not hydrogen and with the proviso that when m is equal to 1 and one of R and R 1 is hydrogen, the other of R or R 1 is not lower alkoxy of from 1 to 4 carbon atoms; and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
137 words
A compound selected from a base of the formula ##SPC11## wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; each of R and R 1 is selected from the group consisting of hydrogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a halogen atom, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, phenyl, phenoxy, a lower alkoxy group of from 1 to 4 carbon atoms, with the proviso that both R and R 1 are not hydrogen and with the proviso that when m is equal to 1 and one of R and R 1 is hydrogen, the other of R or R 1 is not lower alkoxy of from 1 to 4 carbon atoms; and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
53 words
A compound of claim 1 wherein each of R and R 1 is selected from the group consisting of a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a halogen atom, trifluoromethyl, trifluoromethylthio trifluoromethoxy, phenyl, phenoxy and a lower alkoxy group of from 1 to 4 carbon atoms.
Claim 4
Dependent Claim
13 words
A compound of claim 2 wherein n is the integer 4 or 5.
Claim 5
Dependent Claim
15 words
A compound of claim 3 which is 2-[(α-{p-chlorophenyl}-m-trifluoromethylbenzyl)imino]hexahydroazepine and pharmaceutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
78 words
A compound of claim 1 wherein R is hydrogen and R 1 is selected from the group consisting of a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a halogen atom, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, phenyl, phenoxy, and a lower alkoxy group of from 1 to 4 carbon atoms with the proviso that when m is equal to 1, R 1 is not a lower alkoxy group of from 1 to 4 carbon atoms.
Claim 7
Dependent Claim
13 words
A compound of claim 5 wherein n is the integer 4 or 5.
Claim 8
Dependent Claim
15 words
A compound of claim 6 which is 2-[(p-chloro-α-phenylbenzyl)imino]hexahydroazepine and pharmaceutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
15 words
A compound of claim 6 which is hexahydro-2-[(m-{trifluorometyl}-α-phenylbenzyl)imino]azepine and pharmaceutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
15 words
A compound of claim 6 which is hexahydro-2-[(o-methyl-α-phenylbenzyl)imino]azepine and pharmaceutically acceptable acid addition salts thereof.
References Cited (Backward Citations)
GB1210848A
Cited
US3725435A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-15 | 1979-12-15 | 1980-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-15 | 1983-12-15 | 1984-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-15 | 1987-12-15 | 1988-06-15 | $7700.00 | Window Closed / Lapsed |