US3971777A
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Novel steroids and their use
Assignee: Sanofi Aventis France
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Filing: 1975-09-08
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Granted: 1976-07-27
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Expires: 1995-09-08
Abstract
Abstract Novel (17α)-steroids derivatives optical active isomers or mixtures thereof of the formula ##SPC1## Wherein R is selected from the group consisting of hydrogen and methyl, R 1 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen and ##EQU1## of α-configuration; R 2 is alkyl of 1 to 4 carbon atoms, the dotted lines in the A and B rings represent optional 1 or 2 double bonds in the 1(2) position when R is methyl and in the 6(7) position when Z is hydrogen and X and Y together form the group ##EQU2## and when X is OH, Y is ##EQU3## and M is selected from the group consisting of hydrogen, --NH 4 and alkali metals which have antialdosteronic activity and their preparation.
Inventors
- 👤 Genevieve Rousseau
- 👤 Vesperto Torelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 08:10
CPC Classifications
C; C07; C07J; C07J31/00; C07J31/006; A; A61; A61P; A61P5/00; A61P5/38; A61P7/00; A61P7/10; A61P9/00; A61P9/12; C07J33/00; C07J33/005
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
116 words
A compound of the formula ##SPC15## wherein R is selected from the group consisting of hydrogen and methyl, R 1 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen and ##EQU13## of α-configuration, R 2 is alkyl of 1 to 4 carbon atoms, the dotted lines in the A and B rings represent optional 1 or 2 double bonds in the 1(2) position when R is methyl and in the 6(7) position when Z is hydrogen and X and Y together form the group ##EQU14## and when X is OH, Y is ##EQU15## and M is selected from the group consisting of hydrogen, --NH 4 and alkali metals.
Claim 2
Dependent Claim
116 words
A compound of the formula ##SPC15## wherein R is selected from the group consisting of hydrogen and methyl, R 1 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen and ##EQU13## of α-configuration, R 2 is alkyl of 1 to 4 carbon atoms, the dotted lines in the A and B rings represent optional 1 or 2 double bonds in the 1(2) position when R is methyl and in the 6(7) position when Z is hydrogen and X and Y together form the group ##EQU14## and when X is OH, Y is ##EQU15## and M is selected from the group consisting of hydrogen, --NH 4 and alkali metals.
Claim 3
Dependent Claim
10 words
A compound of claim 1 wherein R 1 is methyl.
Claim 4
Dependent Claim
12 words
A compound of claim 1 wherein X and Y together form ##EQU16##
Claim 5
Dependent Claim
27 words
A compound of claim 1 wherein Y is ##EQU17## M is selected from the group consisting of hydrogen, --NH 4 and alkali metal and X is OH.
Claim 6
Dependent Claim
20 words
A compound of claim 3 wherein Z is hydrogen and there is only a double bond in the 4(5) position.
Claim 7
Dependent Claim
21 words
A compound of claim 3 wherein Z is hydrogen and there are 2 double bonds in the 1(2) and 4(5) positions.
Claim 8
Dependent Claim
21 words
A compound of claim 3 wherein Z is hydrogen and there are 2 double bonds in the 4(5) and 6(7) positions.
Claim 9
Dependent Claim
20 words
A compound of claim 1 wherein Z is ##EQU18## and there is a double bond in the 4(5) position only.
Claim 10
Dependent Claim
22 words
A compound of claim 4 wherein M and Z are hydrogen and there is a double bond in the 4(5) position only.
Claim 11
Dependent Claim
15 words
A compound of claim 1 which is the diastereoisomeric sultine of Δ 4 -(17α)-pregnene-17-ol-3-one-21-sulfinic acid.
Claim 12
Dependent Claim
15 words
A compound of claim 1 which is the diastereoisomeric sultine of 19-nor-Δ 4 -(17α)-pregnene-17-ol-3-one-21-sulfinic acid.
Claim 13
Dependent Claim
16 words
A compound of claim 1 which is the diastereoisomeric sultine of Δ 1 ,4 -(17α)-pregnadiene-17-ol-3-one-21-sulfinic acid.
Claim 14
Dependent Claim
16 words
A compound of claim 1 which is the diastereoisomeric sultine of Δ 4 ,6 -(17α)-pregnadiene-17-ol-3-one-21-sulfinic acid.
Claim 15
Dependent Claim
15 words
A compound of claim 1 which is the diastereoisomeric sultine of 7α-acetylthio-Δ 4 -(17α)-pregnene-17-ol-3-one-21-sulfinic acid.
Claim 16
Dependent Claim
16 words
A compound of claim 1 which is the diastereoisomeric sultine of 19-nor-Δ 4 ,6 -(17α)-pregnadiene-17-ol-3-one-21-sulfinic acid.
Claim 17
Dependent Claim
11 words
A compound of claim 1 which is Δ 4 -(17α)-pregnene-17-ol-3-one-21-sulfinic acid.
Claim 18
Dependent Claim
11 words
A compound of claim 1 which is potassium Δ 4 -(17α)-pregnene-17-ol-3-one-21-sulfinate.
Claim 19
Dependent Claim
31 words
A compound of the formula ##SPC16## wherein R is selected from the group consisting of hydrogen and methyl and AlK and R 1 are alkyl of 1 to 4 carbon atoms.
Claim 20
Dependent Claim
31 words
A compound of the formula ##SPC16## wherein R is selected from the group consisting of hydrogen and methyl and AlK and R 1 are alkyl of 1 to 4 carbon atoms.
Claim 21
Dependent Claim
29 words
A compound of the formula ##SPC17## wherein R is selected from the group consisting of hydrogen and methyl and R 1 is alkyl of 1 to 4 carbon atoms.
Claim 22
Dependent Claim
29 words
A compound of the formula ##SPC17## wherein R is selected from the group consisting of hydrogen and methyl and R 1 is alkyl of 1 to 4 carbon atoms.
Claim 23
Dependent Claim
32 words
A compound of the formula ##SPC18## wherein R is selected from the group consisting of hydrogen and methyl and R 1 and AlK 1 are alkyl of 1 to 4 carbon atoms.
Claim 24
Dependent Claim
32 words
A compound of the formula ##SPC18## wherein R is selected from the group consisting of hydrogen and methyl and R 1 and AlK 1 are alkyl of 1 to 4 carbon atoms.
Claim 25
Dependent Claim
29 words
A compound of the formula ##SPC19## wherein R is selected from the group consisting of hydrogen and methyl and R 1 is alkyl of 1 to 4 carbon atoms.
Claim 26
Dependent Claim
29 words
A compound of the formula ##SPC19## wherein R is selected from the group consisting of hydrogen and methyl and R 1 is alkyl of 1 to 4 carbon atoms.
Claim 27
Dependent Claim
25 words
A composition for treating arterial hypertension and cardiac insufficiency comprising an effective amount of at least one compound of claim 1 and a pharmaceutical carrier.
Claim 28
Dependent Claim
38 words
A method for the treatment of arterial hypertension and cardiac insufficiency in warm-blooded animals comprising administering to warm-blooded animals at least one compound of claim 1 in an amount effect to reduce arterial hypertension and overcome cardiac insufficiency.
Claim 29
Dependent Claim
19 words
The method of claim 23 wherein the compound is the sultine of Δ 4 ,6 -(17α)-pregnadiene-17-ol-3-one-21-sulfinic acid (isomer B).
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |