Halogenated immunoadsorbent

Claim 2

A halogenated immunoadsorbent comprising: a halogenated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said halogenated proteinaceous material containing an amount of halogen sufficient to cause said halogenated immunoadsorbent to be a readily filterable, fine granular precipitate in water at a pH of about 7 and a temperature of about 25 degrees centigrade.

Claim 3

A halogenated immunoadsorbent of claim 1 wherein the halogen is bromine.

Claim 4

A halogenated immunoadsorbent of claim 1 wherein the halogen is iodine.

Claim 5

A halogenated immunoadsorbent of claim 1 wherein said halogenated proteinaceous material is substantially saturated with halogen as determined by titration in an aqueous admixture at a pH of about 8 and a temperature of about 30° centigrade.

Claim 6

A halogenated immunoadsorbent of claim 1, wherein a second immunologically reactive protein is immunologically adsorbed on the immunologically reactive protein, said halogenated proteinaceous material is substantially saturated with halogen as determined by titration in an aqueous admixture at a pH of about 8 and a temperature of about 30° centigrade.

Claim 7

A halogenated immunoadsorbent of claim 5, wherein the second immunologically reactive protein is combined with a detectable amount of a labeling material.

Claim 8

A halogenated immunoadsorbent of claim 1 wherein the halogen is a mixture of halogens.

Claim 9

An iodinated immunoadsorbent comprising: an iodinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said iodinated proteinaceous material containing an amount of iodine sufficient to cause said iodinated immunoadsorbent to be a readily filterable, fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade.

Claim 10

An iodinated immunoadsorbent comprising: an iodinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said iodinated proteinaceous material containing an amount of iodine sufficient to cause said iodinated immunoadsorbent to be a readily filterable, fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade.

Claim 11

An iodinated immunoadsorbent of claim 8 wherein said proteinaceous material is substantially saturated with iodine as determined by titration in an aqueous admixture at a pH of about 8 and a temperature of about 30° centigrade.

Claim 12

A brominated immunoadsorbent comprising: a brominated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said brominated proteinaceous material containing an amount of bromine sufficient to cause said brominated immunoadsorbent to be a readily filterable, fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade.

Claim 13

A brominated immunoadsorbent comprising: a brominated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said brominated proteinaceous material containing an amount of bromine sufficient to cause said brominated immunoadsorbent to be a readily filterable, fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade.

Claim 14

An iodinated immunoadsorbent comprising: an iodinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said iodinated immunoadsorbent containing at least about 0.008 mole of iodine and up to an amount of iodine sufficient to substantially saturate said iodinated proteinaceous material for each 100 grams of iodinated immunoadsorbent.

Claim 15

An iodinated immunoadsorbent comprising: an iodinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said iodinated immunoadsorbent containing at least about 0.008 mole of iodine and up to an amount of iodine sufficient to substantially saturate said iodinated proteinaceous material for each 100 grams of iodinated immunoadsorbent.

Claim 16

A brominated immunoadsorbent comprising: a brominated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said brominated immunoadsorbent containing at least about 0.008 mole of bromine and up to an amount of bromine sufficient to substantially saturate said brominated proteinaceous material for each 100 grams of brominated immunoadsorbent.

Claim 17

A brominated immunoadsorbent comprising: a brominated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said brominated immunoadsorbent containing at least about 0.008 mole of bromine and up to an amount of bromine sufficient to substantially saturate said brominated proteinaceous material for each 100 grams of brominated immunoadsorbent.

Claim 18

A chlorinated immunoadsorbent comprising: a chlorinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said chlorinated immunoadsorbent containing at least about 0.025 mole of chlorine and up to an amount of chlorine sufficient to substantially saturate said chlorinated proteinaceous material for each 100 grams of chlorinated immunoadsorbent.

Claim 19

A chlorinated immunoadsorbent comprising: a chlorinated proteinaceous material polymerized with an immunologically reactive protein, which immunologically reactive protein has a specific immune response, said chlorinated immunoadsorbent containing at least about 0.025 mole of chlorine and up to an amount of chlorine sufficient to substantially saturate said chlorinated proteinaceous material for each 100 grams of chlorinated immunoadsorbent.

Claim 20

A process comprising: halogenating a proteinaceous material in an aqueous admixture at a pH of from about 6.8 to 10 and a temperature of from about 15° centigrade to 40° centigrade to produce halogenated proteinaceous material; polymerizing said halogenated proteinaceous material with an immunologically reactive protein, which immunologically reactive protein has a specific predetermined immune reaction, to produce a halogenated immunoadsorbent.

Claim 21

A process comprising: halogenating a proteinaceous material in an aqueous admixture at a pH of from about 6.8 to 10 and a temperature of from about 15° centigrade to 40° centigrade to produce halogenated proteinaceous material; polymerizing said halogenated proteinaceous material with an immunologically reactive protein, which immunologically reactive protein has a specific predetermined immune reaction, to produce a halogenated immunoadsorbent.

Claim 22

A process of claim 14 including halogenating the proteinaceous material with an amount of iodine sufficient to produce a halogenated immunoadsorbent in which the iodine is present in an amount of at least about 0.008 mole per 100 grams of said halogenated immunoadsorbent and up to an amount where said halogenated proteinaceous material is substantially saturated with iodine.

Claim 23

An iodinated immunoadsorbent of claim 8 wherein a second immunologically reactive protein is immunologically adsorbed on the immunologically reactive protein, said iodinated proteinaceous material is substantially saturated with iodine as determined by titration in an aqueous admixture at a pH of about 8 and a temperature of about 30° centigrade.

Claim 24

An iodinated immunoadsorbent of claim 16, wherein the second immmunologically reactive protein is combined with a detectable amount of labeling material.

Claim 25

An iodinated immunoadsorbent of claim 17 wherein the labeling material is radioactive iodine.

Claim 26

A physical admixture comprising: polymerized halogenated proteinaceous material and an immunoadsorbent, said immunoadsorbent consisting essentially of a protein material polymerized with an immunologically reactive protein which immunologically reactive protein has a specific immune response, said polymerized halogenated proteinaceous material being formed by polymerizing halogenated proteinaceous material and containing an amount of halogen sufficient to cause said polymerized halogenated proteinaceous material to be a fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade, said immunoadsorbent being a near colloidal suspension in water at a pH of about 7 and a temperature of about 25° centigrade.

Claim 27

A physical admixture comprising: polymerized halogenated proteinaceous material and an immunoadsorbent, said immunoadsorbent consisting essentially of a protein material polymerized with an immunologically reactive protein which immunologically reactive protein has a specific immune response, said polymerized halogenated proteinaceous material being formed by polymerizing halogenated proteinaceous material and containing an amount of halogen sufficient to cause said polymerized halogenated proteinaceous material to be a fine granular precipitate in water at a pH of about 7 and a temperature of about 25° centigrade, said immunoadsorbent being a near colloidal suspension in water at a pH of about 7 and a temperature of about 25° centigrade.