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US4001298A Expired / Lapsed US ⏱️ 0.0 years remaining

Triiodized n-methyldicarboxylic acid anilides

Assignee: Bayer Pharma AG
•
Filing: 1972-08-17
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Granted: 1977-01-04
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Expires: 1992-08-17
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Abstract

Abstract Triiodized N-methyldicarboxylic acid anilides of the Formula ##STR1## wherein R 1 is hydrogen, halogen, carboxyl, N-monoacylamino, N-monoalkoxyacylamino, N-alkyl-N-acylamino, N-alkyl-N-alkoxyacylamino, N,N-diacylamino, N-acylaminomethyl, ##STR2## wherein A is alkylene of 2 or 3 carbon atoms which can be interrupted by an oxygen atom, and R 3 and R 4 are each hydrogen, lower alkyl or hydroxyalkyl, or R 3 and R 4 together with the nitrogen atom form a 5 to 7 member heterocyclic ring which can contain a further oxygen, nitrogen, or sulfur hetero atom; R 2 is halogen, hydroxy, lower alkoxy, hydroxyalkoxy or alkoxyalkoxy; and X is straight or branched alkylene of 2-14 carbon atoms interrupted by one or more oxygen or sulfur atoms, and the salts of these compounds with physiologically compatible bases are valuable radiopaque agents.

Inventors

  • 👤 Heinz Gries
  • 👤 Heinrich Pfeiffer

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 22:42
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/263; C07D207/27; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433

Claims Analysis

Total Claims: 15
Claim 1
Independent Claim 57 words
A triiodized N-methyldicarboxylic acid anilide of the formula ##STR10## wherein R 1 is hydrogen or halogen, carboxyl, R 2 is chlorine, hydroxy, lower alkoxy, hydroxyalkoxy or alkoxyalkoxy, alkoxy in each instance being of 1-6 carbon atoms; and X is alkylene of 2-14 carbon atoms interrupted by at least one oxygen atom, or a physiologically acceptable salt thereof.
Claim 2
Dependent Claim 57 words
A triiodized N-methyldicarboxylic acid anilide of the formula ##STR10## wherein R 1 is hydrogen or halogen, carboxyl, R 2 is chlorine, hydroxy, lower alkoxy, hydroxyalkoxy or alkoxyalkoxy, alkoxy in each instance being of 1-6 carbon atoms; and X is alkylene of 2-14 carbon atoms interrupted by at least one oxygen atom, or a physiologically acceptable salt thereof.
Claim 3
Dependent Claim 10 words
A compound of claim 1, wherein R 1 is hydrogen.
Claim 4
Dependent Claim 10 words
A compound of claim 1, wherein R 1 is halogen.
Claim 5
Dependent Claim 10 words
A compound of claim 1, wherein R 1 is carboxyl.
Claim 6
Dependent Claim 19 words
A compound of claim 1, wherein X is alkylene of 2-6 carbon atoms interrupted by a single oxygen atom.
Claim 7
Dependent Claim 25 words
A compound of claim 1, wherein X is alkylene of 2-14 carbon atoms interrupted at every second or third carbon atom by an oxygen atom.
Claim 8
Dependent Claim 9 words
A compound according to claim 1, diglycolic acid di-(3-chlorocarbonyl-2,4,6-triiodo-N-methylanilide).
Claim 9
Dependent Claim 9 words
A compound according to claim 1, diglycolic acid di-(3-carboxy-2,4,6-triiodo-N-methyl-anilide).
Claim 10
Dependent Claim 9 words
A compound according to claim 1, 3,6,9-trioxaundecanedioic acid di-(3-carboxy-2,4,6-triiodo-N-methylanilide).
Claim 11
Dependent Claim 9 words
A compound according to claim 1,, diglycolic acid di-(3-methoxycarbonyl-2,4,6-triiodo-N-methylanilide).
Claim 12
Dependent Claim 9 words
A compound according to claim 1, diglycolic acid di-(3,5-dicarboxy-2,4,6-triiodo-N-methylanilide).
Claim 13
Dependent Claim 9 words
A compound according to claim 1, 4,7,10,13-tetraoxahexadecane-1,16-dioic acid di-(3-carboxy-2,4,6-triiodo-N-methylanilide).
Claim 14
Dependent Claim 9 words
A compound according to claim 1, diglycolic acid di-(3-carboxy-5-chloro-2,4,6-triiodo-N-methylanilide).
Claim 15
Dependent Claim 9 words
A compound according to claim 1, 3,6-dioxasuberic acid di-(3-carboxy-2,4,6-triiodo-N-methylanilide).

References Cited (Backward Citations)

US3542861A Cited
US3732293A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-01-04 1980-07-05 1981-01-04 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-01-04 1984-07-05 1985-01-04 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-01-04 1988-07-05 1989-01-04 $7700.00 Window Closed / Lapsed

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