US4002530A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-Aminopenicillanic acid derivative
Assignee: Recherche et Industrie Therapeutiques
•
Filing: 1975-01-09
•
Granted: 1977-01-11
•
Expires: 1995-01-09
Abstract
Abstract Penicillin derivative substituted at the 6 position with a (D)-[(2-amino-2-carboxy)-ethylthio]-acetamido group is obtained from Acremonium Chrysogenum new strain ATCC 20 389 or by semi-synthetic route. The product is an antibacterial agent.
Inventors
- 👤 Hugo Troonen
- 👤 Piet Roelants
- 👤 Bernard Boon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:16
CPC Classifications
C; C07; C07D; C07D499/00; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
49 words
A method of producing the compound 6-[(D)-(2-amino-2-carboxyethylthio)acetamido]penicillanic acid of the formula ##STR3## which comprises cultivating Acremonium chrysogenum ATCC 20,389 in a culture medium containing assimilable sources of carbon and nitrogen, inorganic salts, L-lysine, and L-carboxymethylcysteine under submerged aerobic conditions until a substantial amount of the said compound is produced.
Claim 2
Independent Claim
49 words
A method of producing the compound 6-[(D)-(2-amino-2-carboxyethylthio)acetamido]penicillanic acid of the formula ##STR3## which comprises cultivating Acremonium chrysogenum ATCC 20,389 in a culture medium containing assimilable sources of carbon and nitrogen, inorganic salts, L-lysine, and L-carboxymethylcysteine under submerged aerobic conditions until a substantial amount of the said compound is produced.
Claim 3
Dependent Claim
47 words
A method according to claim 1, wherein the culture medium contains L (+) lysine and is maintained at a temperature of from approximately 20° C to approximately 37° C and the growth of the organism is carried out for a period of approximately 36 to 96 hours.
Claim 4
Dependent Claim
16 words
A method according to claim 2 additionally comprising recovering the said compound from said culture medium.
References Cited (Backward Citations)
US3024168A
Cited
US3093547A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-11 | 1980-07-12 | 1981-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-11 | 1984-07-12 | 1985-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-11 | 1988-07-12 | 1989-01-11 | $7700.00 | Window Closed / Lapsed |