US4007266A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical composition containing vitamin B12, process of making the same and method of treatment
Assignee: Choay SA
•
Filing: 1975-02-26
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Granted: 1977-02-08
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Expires: 1995-02-26
Abstract
Abstract A pharmaceutical composition for the treatment of disorders in the formation or regeneration of the cutaneous connective tissue including disorders due to aging of the skin, which composition comprises a homogeneous mixture of vitamin B12 in an amount effective for the above treatment and a carrier vehicle therefor. The carrier vehicle is a fatty skin cream of a pH between about 4 and 7 which is non-oxidizing and non-reducing and is pharmaceutically acceptable for repeated applications to the skin over prolonged periods of time.
Inventors
- 👤 Jean Choay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:38
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K8/67; A61K8/673; A61K8/96; A61K8/98; A61K8/981; A61K8/982; A61Q; A61Q19/00; A61Q19/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
111 words
A method for the treatment of an animal or human patient suffering from a loss of elasticity or loss of thickness of the skin or from excessive dryness of the skin due to aging of the skin, the said method comprising applying topically to the affected area of the skin an effective amount of a pharmaceutical composition comprising a homogeneous mixture of an aqueous solution of cyanocobalamin or hydroxycyanocobalamin and a pharmaceutically acceptable percutaneous penetration vehicle therefor, the said composition having a pH between about 4.0 and 7.0, being resistant to both oxidation and reduction, and being pharmaceutically acceptable for repeated application to cutaneous connective tissue over prolonged periods of time.
Claim 2
Independent Claim
111 words
A method for the treatment of an animal or human patient suffering from a loss of elasticity or loss of thickness of the skin or from excessive dryness of the skin due to aging of the skin, the said method comprising applying topically to the affected area of the skin an effective amount of a pharmaceutical composition comprising a homogeneous mixture of an aqueous solution of cyanocobalamin or hydroxycyanocobalamin and a pharmaceutically acceptable percutaneous penetration vehicle therefor, the said composition having a pH between about 4.0 and 7.0, being resistant to both oxidation and reduction, and being pharmaceutically acceptable for repeated application to cutaneous connective tissue over prolonged periods of time.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein the percutaneous penetration vehicle consists of a fatty skin cream.
Claim 4
Dependent Claim
23 words
A method as defined in claim 1 in which the composition contains between 1 and 100 micrograms per gram of cyanocobalamin or hydroxycyanocobalamin.
Claim 5
Dependent Claim
22 words
A method as defined in claim 1 in which the composition includes N-propionyl-epsilon-aminocaproic acid or a sodium, calcium, or magnesium salt thereof.
Claim 6
Dependent Claim
38 words
A method as defined in claim 3 in which the N-propionyl-epsilon-aminocaproic acid or a sodium, calcium or magnesium salt is present in the composition in an amount of at least 10 and at most 50 milligrams per gram.
Claim 7
Dependent Claim
14 words
A method as defined in claim 1 in which the composition includes ribonucleic acid.
Claim 8
Dependent Claim
31 words
A method as defined in claim 6 in which the ribonucleic acid is present in the composition in an amount between at least 0.25 and at most 1 milligram per gram.
Claim 9
Dependent Claim
45 words
A method as defined in claim 1 in which the composition includes chicken embryo extract prepared by extraction of chicken embryos with an aqueous solution of sodium chloride in the proportions of 1 gram of chicken embryos to 1 milliliter of the sodium chloride solution.
Claim 10
Dependent Claim
32 words
A method as defined in claim 8 in which the chicken embryo extract is present in the composition in an amount of at least 0.0005 and at most 0.05 milliliter per gram.
Claim 11
Dependent Claim
34 words
A method as defined in claim 1 in which the composition is applied topically to the affected area of the cutaneous tissue at least once daily for a period of at least 3 days.
Claim 12
Dependent Claim
19 words
A method as defined in claim 1 in which said percutaneous penetration vehicle consists of a fatty skin cream.
References Cited (Backward Citations)
US2579679A
Cited
FR1096225A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-08 | 1980-08-09 | 1981-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-08 | 1984-08-09 | 1985-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-08 | 1988-08-09 | 1989-02-08 | $7700.00 | Window Closed / Lapsed |