7-Acylamino-3-acyl-2(or 3)cephems

Claim 1

The compound of the formula ##STR35##wherein Z is a group of the formula ##STR36##wherein R is a group of the formula --OR 5 wherein R 5 is hydrogen or a carboxylic acid protecting ester forming group; R 4 taken together with Y forms a carbon-oxygen double bond; and R 3 is C 1 -C 6 alkyl, vinyl, allyl, ethynyl, benzyl, or phenyl; and R 1 is an acyl group of the formula ##STR37##wherein R' is (a) C 1 -C 6 alkyl, C 3 -C 7 alkenyl, cyanomethyl, halomethyl, 4-amino-4-carboxybutyl, 4-protected amino-4-protected carboxybutyl; or (b) benzyloxy, 4-nitrobenzyloxy or 4-methoxybenzyloxy; or (c) the group -R" wherein R" is 1,4-cyclohexadienyl, phenyl or substituted phenyl wherein the substituents are 1-3 halogens, hydroxy, nitro, cyano, trifluoromethyl, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, carboxy, carboxymethyl, hydroxymethyl, aminomethyl or protected aminomethyl; or (d) an arylalkyl group of the formula R"--(Y).sub.m --CH.sub.2 -- wherein R" is as defined above, Y is O or S, and m is 0 or 1; or (e) a substituted arylalkyl group of the formula ##STR38## wherein R'" is R" as defined above, 2-thienyl or 3-thienyl, W is hydroxy or protected hydroxy, carboxy or protected carboxy, amino or protected amino; or (f) a heteroarylmethyl group of the formula R""--CH.sub.2 -- wherein R"" is 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-thiazolyl, 5-tetrazolyl or 1-tetrazolyl; and R 2 is hydrogen or methoxy; and when R 5 is hydrogen, the pharmaceutically acceptable non-toxic salts of the acids represented thereby.