Patent US1330693A successfully refreshed from Google Patents.
US4017614A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions for the relief of migraine
Assignee: Individual
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Filing: 1975-12-05
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Granted: 1977-04-12
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Expires: 1995-12-05
Abstract
Abstract The invention is predicated on the discovery that certain 1,4-disubstituted piperazines interact synergistically with certain known analgesics to antagonize or block the stimulus causing migraine. This effect is most pronounced when administering a mixture of 1-p-chlorobenzhydryl-4-p-(tertiary butyl)-benzyl-piperazine (buclizine) and N-acetyl-p-aminophenol (paracetamol) in the respective proportions by weight of from 1:20 to 1:200.
Inventors
- 👤 Henry Wild
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/60
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
108 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising: a. 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine and (b) a compound selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxy-acetanilide, salicylamide and acetylsalicylic acid, the piperazine (a) and the compound (b) being respectively present in a weight ratio of 1:20 to 1:200, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg.
Claim 2
Independent Claim
108 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising: a. 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine and (b) a compound selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxy-acetanilide, salicylamide and acetylsalicylic acid, the piperazine (a) and the compound (b) being respectively present in a weight ratio of 1:20 to 1:200, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg.
Claim 3
Independent Claim
112 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising component (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine and as component (b) at least two compounds selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxy-acetanilide, salicylamide and acetylsalicylic acid, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg., the piperazine (a) and said component (b) being respectively present in a weight ratio 1:20 to 1:200.
Claim 4
Independent Claim
112 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising component (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine and as component (b) at least two compounds selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxy-acetanilide, salicylamide and acetylsalicylic acid, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg., the piperazine (a) and said component (b) being respectively present in a weight ratio 1:20 to 1:200.
Claim 5
Independent Claim
81 words
A method for preventing or diminishing the severity of a migraine attack by a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine in an amount of 2.5 to 24 mg., (b) 200 to 1500 mg. of N-acetyl-p-aminophenol and (c) 7.5 to 22.5 mg. of codeine per 1 gram of said N-acetyl-p-aminophenol.
Claim 6
Independent Claim
81 words
A method for preventing or diminishing the severity of a migraine attack by a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine in an amount of 2.5 to 24 mg., (b) 200 to 1500 mg. of N-acetyl-p-aminophenol and (c) 7.5 to 22.5 mg. of codeine per 1 gram of said N-acetyl-p-aminophenol.
Claim 7
Independent Claim
66 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or a premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising (a) 2.5 to 24 mg. of 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine and (b) 200 to 1500 mg. of N-acetyl-p-aminophenol.
Claim 8
Independent Claim
66 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or a premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising (a) 2.5 to 24 mg. of 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine and (b) 200 to 1500 mg. of N-acetyl-p-aminophenol.
Claim 9
Dependent Claim
27 words
The method of claim 2, wherein said piperazine (a) and said component (b) are present in relative proportions by weight within the range 1:40 to 1:120, respectively.
Claim 10
Dependent Claim
13 words
The method of claim 5, wherein said range is from 1:70 to 1:100.
Claim 11
Dependent Claim
21 words
The method of claim 2, in which the component (b) is present in an amount of from 200 to 1500 mg.
Claim 12
Dependent Claim
20 words
The method of claim 7, wherein the component (b) is present in an amount of from 300 to 1000 mg.
Claim 13
Dependent Claim
28 words
The method of claim 3 wherein said piperazine (a) and said N-acetyl-p-aminophenol (b) are present in relative proportions by weight within the range of 1:40 to 1:120, respectively.
Claim 14
Dependent Claim
14 words
The method of claim 9, in which said range is from 1:70 to 1:100.
Claim 15
Dependent Claim
19 words
The method of claim 3, wherein said N-acetyl-p-aminophenol is present in an amount of from 200 to 1500 mg.
Claim 16
Independent Claim
133 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising component (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine, component (b) at least wo compounds selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxyacetanilide, salicylamide and acetylsalicylic acid and as component (c) codeine, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg., the piperazine (a) and said component (b) being respectively present in a weight ratio of 1:20 to 1:200, the amound of codeine being from 7.5 to 22.5 mg. per 1 gram of said component (b).
Claim 17
Independent Claim
133 words
A method for preventing or diminishing the severity of a migraine attack of a migraneous individual comprising prophylactically administering to said individual after onset of an aura or premonition of a migraine attack by said individual or during an episodic pattern of migraine attacks, a composition comprising component (a) 1-p-chlorobenzhydryl 4-p-(tertiary butyl)-benzyl piperazine or a pharmaceutically acceptable addition salt of said piperazine, component (b) at least wo compounds selected from the group consisting of N-acetyl-p-aminophenol, p-ethoxyacetanilide, salicylamide and acetylsalicylic acid and as component (c) codeine, the dosage unit of said piperazine (a) ranging from 2.5 to 24 mg., the piperazine (a) and said component (b) being respectively present in a weight ratio of 1:20 to 1:200, the amound of codeine being from 7.5 to 22.5 mg. per 1 gram of said component (b).
Claim 18
Dependent Claim
27 words
The method of claim 12 wherein said piperazine (a) and said component (b) are present in relative proportion by weight within the range 1:40 to 1:120, respectively.
Claim 19
Dependent Claim
13 words
The method of claim 13, wherein said range is from 1:70 to 1:100.
Claim 20
Dependent Claim
20 words
The method of claim 12 in which component (b) is present in an amount of from 200 to 1500 mg.
Claim 21
Dependent Claim
20 words
The method of claim 15 wherein said component (b) is present in an amount of from 300 to 1000 mg.
References Cited (Backward Citations)
GB705979A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |