US4018893A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for treating microbial infections
Assignee: Merck Sharp & Dohme LLC
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Filing: 1975-12-12
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Granted: 1977-04-19
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Expires: 1995-12-12
Abstract
Abstract Disclosed herein are 2-aminoalkyl-3-aryl-benzothiophenes and benzofurans useful as antimicrobial agents.
Inventors
- 👤 Martin Steinman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 12:33
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/81; A; A23; A23B; A23B2/00; A23B2/70; A23B2/725; A23B2/729; A23B2/771; C07D333/00; C07D333/50; C07D333/52; C07D333/62; C07D333/68; C07D333/70
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
132 words
A method for treating susceptible microbial infections, selected from the group consisting of bacterial, fungal and protozoal infections, which comprises administering to an animal species so infected an antimicrobially effective quantity of a compound represented by the formula: ##STR2## wherein n is 0 or 1 R 2 is hydrogen, or amino lower alkylene having 1 to 3 carbon atoms; R 1 is carbonyl or lower alkylene having 1 to 3 carbon atoms with the proviso that when R 2 is hydrogen, R 1 is lower alkylene; T is 0; X is halogen, nitro, or trifluoromethyl; Y is hydrogen, halogen, methyl or trifluoromethyl; M is hydrogen, halogen or methyl with the proviso that when X is nitro, M is halogen; Z is hydrogen, halogen, nitro or methyl; or the acid addition salts thereof.
Claim 2
Independent Claim
132 words
A method for treating susceptible microbial infections, selected from the group consisting of bacterial, fungal and protozoal infections, which comprises administering to an animal species so infected an antimicrobially effective quantity of a compound represented by the formula: ##STR2## wherein n is 0 or 1 R 2 is hydrogen, or amino lower alkylene having 1 to 3 carbon atoms; R 1 is carbonyl or lower alkylene having 1 to 3 carbon atoms with the proviso that when R 2 is hydrogen, R 1 is lower alkylene; T is 0; X is halogen, nitro, or trifluoromethyl; Y is hydrogen, halogen, methyl or trifluoromethyl; M is hydrogen, halogen or methyl with the proviso that when X is nitro, M is halogen; Z is hydrogen, halogen, nitro or methyl; or the acid addition salts thereof.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein n is 0.
Claim 4
Dependent Claim
9 words
The method of claim 1 wherein X is chloro.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein R 2 is hydrogen.
Claim 6
Dependent Claim
10 words
The method of claim 1 wherein R 1 is methylene.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein M and Z are dihalo.
Claim 8
Dependent Claim
12 words
The method of claim 6 wherein M and Z are each chloro.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein said compound is 2-aminomethyl-5-chloro-3-phenylbenzofuran.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein said compound is 2-aminomethyl-5-chloro-3-(2,4-dichlorophenyl) benzofuran.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-18 | 1980-10-18 | 1981-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-18 | 1984-10-18 | 1985-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-18 | 1988-10-18 | 1989-04-19 | $7700.00 | Window Closed / Lapsed |