US4024237A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel compositions for establishing environmental conditions favorable to oral leucocytes
Assignee: Individual
•
Filing: 1975-08-04
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Granted: 1977-05-17
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Expires: 1995-08-04
Abstract
Abstract Novel compositions for establishing environmental conditions in the human oral cavity for maintaining healthy, functional oral leucocytes, said compositions comprising a non-toxic mixture of effective amounts of: (1) at least one compound for maintaining a colloidal and viscous environment within the oral cavity which favors and promotes oral leucocyte locomotion, phagocytosis and bacterial kill; (2) at least one compound providing and maintaining a balanced ionic environment which favors and promotes locomotion, phagocytosis and bacterial kill; (3) at least one compound providing a source of energy for said oral leucocytes; and (4) at least one compound for maintaining substantially a physiological pH to promote leucocyte functions while avoiding other tissue and cell injury; and novel products and processes employing the same.
Inventors
- 👤 Bertram Eichel
- 👤 Vincent F. Lisanti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 13:02
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/24; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61K8/60; A61K8/72; A61K8/73; A61K8/735; A61Q; A61Q11/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
150 words
A composition for establishing environmental conditions in the human oral cavity for maintaining healthy functional oral leucocytes, said composition comprising a non-toxic mixture of effective amounts of: (1) at least one compound selected from the group consisting of dextran, cellulose ethers, polyvinylpyrrolidone and gelatin for maintaining a colloidal and viscous environment within the oral cavity which favors and promotes oral leucocyte locomotion, phagocytosis and bacterial kill; (2) at least one compound selected from the group consisting of carbohydrates, fats and proteins to provide a source of energy for said oral leucocytes; (3) an inorganic salt providing and maintaining a balanced ionic environment which favors and promotes locomotion, phagocytosis and bacterial kill; and (4) at least one compound selected from the group consisting of phosphate buffers, carbon dioxide-bicarbonate buffers, tris buffers and glycylglycine buffers for maintaining substantially a physiological pH to promote leucocyte functions while avoiding other tissue and cell injury.
Claim 2
Dependent Claim
150 words
A composition for establishing environmental conditions in the human oral cavity for maintaining healthy functional oral leucocytes, said composition comprising a non-toxic mixture of effective amounts of: (1) at least one compound selected from the group consisting of dextran, cellulose ethers, polyvinylpyrrolidone and gelatin for maintaining a colloidal and viscous environment within the oral cavity which favors and promotes oral leucocyte locomotion, phagocytosis and bacterial kill; (2) at least one compound selected from the group consisting of carbohydrates, fats and proteins to provide a source of energy for said oral leucocytes; (3) an inorganic salt providing and maintaining a balanced ionic environment which favors and promotes locomotion, phagocytosis and bacterial kill; and (4) at least one compound selected from the group consisting of phosphate buffers, carbon dioxide-bicarbonate buffers, tris buffers and glycylglycine buffers for maintaining substantially a physiological pH to promote leucocyte functions while avoiding other tissue and cell injury.
Claim 3
Dependent Claim
17 words
A composition as defined in claim 1 wherein said pH is from about 5.5 to about 9.
Claim 4
Dependent Claim
31 words
A composition as defined in claim 1 including at least one additional reagent selected from the group consisting of anti-caries agents, flavoring agents, effervescing agents, preservatives, colorants, viscous reagents and solvents.
Claim 5
Dependent Claim
62 words
A composition as defined in claim 1 wherein said first mentioned compound is present in an amount of from 0.5 to 10.0 parts by weight; said second mentioned compound in from 0.1 to 3.0 parts by weight; said third mentioned compound in from 0.26 to 5.2 parts by weight; and said last mentioned compound in from 0.015 to 1.5 parts by weight.
Claim 6
Dependent Claim
13 words
A solution, toothpaste or powder comprising a composition as defined in claim 1.
Claim 7
Dependent Claim
70 words
A composition as defined in claim 4 wherein said compound providing a colloidal and viscous environment is dextran; said compound providing a source of energy is glucose; said balanced ionic environment is provided by a mixture of compounds comprising sodium chloride, sodium bicarbonate, calcium chloride, potassium chloride, monopotassium dihydrogen phosphate and magnesium sulfate; and said physiological pH is provided by the interaction of sodium bicarbonate and tartaric or citric acid.
Claim 8
Dependent Claim
13 words
A process which comprises applying orally a composition as defined in claim 1.
Claim 9
Dependent Claim
21 words
A process as defined in claim 7 wherein said composition is applied as a solution, slurry, powder or as a toothpaste.
Claim 10
Dependent Claim
45 words
A composition as defined in claim 1 including at least one compound selected from the group consisting of heparin, chondroitin sulfate and polyanionic polysaccharides to provide a negative charge potential whereby to reduce clustering of leucocytes and to eliminate agglutination and precipitation of protoplasmic particles.
References Cited (Backward Citations)
US2025655A
Cited
US2042359A
Cited
US2779708A
Cited
US3232833A
Cited
US3510561A
Cited
US3506642A
Cited
US3839590A
Cited
US3651207A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-16 | 1980-11-15 | 1981-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-16 | 1984-11-15 | 1985-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-16 | 1988-11-15 | 1989-05-17 | $7700.00 | Window Closed / Lapsed |