Patent US3221002A successfully refreshed from Google Patents.
US4025501A
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Polypeptide propoxyphene derivatives for immunoassay reagents
Assignee: Syva Co
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Filing: 1975-03-20
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Granted: 1977-05-24
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Expires: 1995-03-20
Abstract
Abstract Novel compounds are provided which are derivatives of 1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol. The indicated alcohol is employed to prepare the monoester of a dibasic acid which is conjugated with an antigen for the production of antibodies which recognize both propoxyphene and its N-desmethyl metabolite in immunoassays.
Inventors
- 👤 Richard K. Leute
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 10:28
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S435/964; Y10S436/00; Y10S436/823; Y10S530/00; Y10S530/806; Y10S530/807
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
91 words
Compounds of the formula: ##STR5## wherein: R is a bond or divalent aliphatic radical having from 0 to 1 site of ethylenic unsaturation and of from 1 to 5 carbon atoms; X is an anion of a strong mineral acid; m is equal to the valence of X; n is 0 to 1 divided by m; Z is a polypeptide residue; and p is equal to at least 1 and not greater than the molecular weight of Z divided by 500; wherein the bonds to Z are through an amide link.
Claim 2
Dependent Claim
91 words
Compounds of the formula: ##STR5## wherein: R is a bond or divalent aliphatic radical having from 0 to 1 site of ethylenic unsaturation and of from 1 to 5 carbon atoms; X is an anion of a strong mineral acid; m is equal to the valence of X; n is 0 to 1 divided by m; Z is a polypeptide residue; and p is equal to at least 1 and not greater than the molecular weight of Z divided by 500; wherein the bonds to Z are through an amide link.
Claim 3
Dependent Claim
78 words
A compound of the formula: (M--R.sup.2 --CO-).sub.n' Y' wherein: Y' is an antigenic polypeptide residue; R 2 is an aliphatic divalent radical having from 0 to 1 site of ethylenic unsaturation and of from 1 to 5 carbon atoms; M is the residue bonded to R 2 of the formula: ##STR6## n' ranges on the average from the molecular weight of the protein divided by about 500 to the molecular weight of the protein divided by about 50,000.
Claim 4
Dependent Claim
78 words
A compound of the formula: (M--R.sup.2 --CO-).sub.n' Y' wherein: Y' is an antigenic polypeptide residue; R 2 is an aliphatic divalent radical having from 0 to 1 site of ethylenic unsaturation and of from 1 to 5 carbon atoms; M is the residue bonded to R 2 of the formula: ##STR6## n' ranges on the average from the molecular weight of the protein divided by about 500 to the molecular weight of the protein divided by about 50,000.
Claim 5
Dependent Claim
27 words
A compound according to Claim 2, wherein n' is on the average from 2 to 250 and R 2 is of from 2 to 4 carbon atoms.
Claim 6
Dependent Claim
14 words
A composition according to claim 3, wherein R 2 is of 2 carbon atoms.
Claim 7
Dependent Claim
19 words
Antibodies prepared in response to an antigen according to claim 2, capable of binding to said antigen and propoxyphene.
Claim 8
Dependent Claim
19 words
Antibodies prepared in response to said composition of claim 6, and capable of binding to said composition and propoxyphene.
Claim 9
Dependent Claim
19 words
Antibodies prepared in response to said composition of claim 4, and capable of binding to said composition and propoxyphene.
Claim 10
Dependent Claim
30 words
A compound of the formula ##STR7## wherein: p is at least 1 and not greater than the molecular weight of BSA divided by 1500, and BSA is bovine serum albumin.
Claim 11
Dependent Claim
30 words
A compound of the formula ##STR7## wherein: p is at least 1 and not greater than the molecular weight of BSA divided by 1500, and BSA is bovine serum albumin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-23 | 1980-11-22 | 1981-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-23 | 1984-11-22 | 1985-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-23 | 1988-11-22 | 1989-05-24 | $7700.00 | Window Closed / Lapsed |