US4039682A
Expired / Lapsed
US
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Method and composition for relief of back pain
Assignee: Knoll Pharmaceutical Co
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Filing: 1976-03-29
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Granted: 1977-08-02
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Expires: 1996-03-29
Abstract
Abstract Back pain and other symptoms of intervertebral disk disease are relieved by injecting into the diseased intervertebral disk of the back an aqueous solution of, for example, in each milliliter of solution: 3.5 mg. of cysteine hydrochloride monohydrate; 0.37 mg. of disodium edetate dihydrate; 1 mg. of sodium bisulfite, 20 mg. of sodium iothalamate; and sufficient sodium hydroxide to provide a pH of about 6.5 to the solution. The solution is free of proteolytic enzymes.
Inventors
- 👤 Robert K. Ausman
- 👤 Ivan J. Stern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/045; A61K31/185; A61K31/19; A61K31/195; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0452
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
44 words
The method of relieving back pain and related symptoms which comprises injecting into an intervertebral disk of the back a formulation which comprises an effective dosage in aqueous solution of cysteine, said formulation being free of proteolytic enzymes and having a generally neutral pH.
Claim 2
Independent Claim
44 words
The method of relieving back pain and related symptoms which comprises injecting into an intervertebral disk of the back a formulation which comprises an effective dosage in aqueous solution of cysteine, said formulation being free of proteolytic enzymes and having a generally neutral pH.
Claim 3
Dependent Claim
27 words
The method of claim 1 in which said cysteine is present in the form of 3 to 50 mg. of cysteine hydrochloride per ml. of said solution.
Claim 4
Dependent Claim
22 words
The method of claim 1 in which from 15 to 25 mg. of sodium Iothalamate are present per ml. of said solution.
Claim 5
Dependent Claim
22 words
The method of claim 1 in which from 0.3 to 0.5 mg. of disodium edetate is present per ml. of said solution.
Claim 6
Dependent Claim
22 words
The method of claim 1 in which from 0.5 to 1.5 mg. of sodium bisulfite is present per ml. of said solution.
Claim 7
Dependent Claim
17 words
The method of claim 1 in which the pH of said solution is from 6 to 7.
Claim 8
Dependent Claim
22 words
The method of claim 3 in which from 0.3 to 0.5 mg. of disodium edetate are present per ml. of said solution.
Claim 9
Dependent Claim
58 words
A formulation for injection into an intervertebral disc of the back for relief of back pain and related symptoms, which comprises: an aqueous solution of an effective dosage of cysteine, said formulation being free of proteolytic enzymes and having a generally neutral pH, and containing from 0.3 to 0.5 mg. of disodium edetate per ml. of said solution.
Claim 10
Dependent Claim
58 words
A formulation for injection into an intervertebral disc of the back for relief of back pain and related symptoms, which comprises: an aqueous solution of an effective dosage of cysteine, said formulation being free of proteolytic enzymes and having a generally neutral pH, and containing from 0.3 to 0.5 mg. of disodium edetate per ml. of said solution.
Claim 11
Dependent Claim
27 words
The formulation of claim 8 in which said cysteine is present in the form of 3 to 50 mg. of cysteine hydrochloride per ml. of said solution.
Claim 12
Dependent Claim
17 words
The formulation of claim 8 in which the pH of said solution is from 6 to 7.
Claim 13
Dependent Claim
21 words
The formulation of claim 8 in which 0.05 to 1.5 mg. of sodium bisulfite is present per ml. of said solution.
Claim 14
Dependent Claim
22 words
The formulation of claim 8 in which from 15 to 25 mg. of sodium Iothalamate are present per ml. of said solution.
Claim 15
Dependent Claim
99 words
A formulation for injection into an intervertebral disk of the back for relief of back pain and related symptoms, which comprises: an aqueous solution comprising from 3 to 5 mg. per ml. of solution of cysteine hydrochloride; from 0.3 to 0.4 mg. per ml. of solution of disodium edetate; from 0.8 to 1.2 mg. per ml. of solution of sodium bisulfite; and from 15 to 25 mg. per ml. of solution of sodium Iothalamate, said solution having sufficient sodium hydroxide added thereto to provide it with a pH of 6 to 7, said formulation being free of proteolytic enzymes.
Claim 16
Dependent Claim
99 words
A formulation for injection into an intervertebral disk of the back for relief of back pain and related symptoms, which comprises: an aqueous solution comprising from 3 to 5 mg. per ml. of solution of cysteine hydrochloride; from 0.3 to 0.4 mg. per ml. of solution of disodium edetate; from 0.8 to 1.2 mg. per ml. of solution of sodium bisulfite; and from 15 to 25 mg. per ml. of solution of sodium Iothalamate, said solution having sufficient sodium hydroxide added thereto to provide it with a pH of 6 to 7, said formulation being free of proteolytic enzymes.
Claim 17
Dependent Claim
61 words
A formulation for injection into an intervertebral disc of the back, for relief of back pain and related symptoms, which comprises: an aqueous solution of an effective dosage of cysteine, in combination with sodium Iothalamate present in a concentration of at least 10 mg. per ml. of solution, said formulation being free of proteolytic enzymes and having a generally neutral pH.
Claim 18
Dependent Claim
61 words
A formulation for injection into an intervertebral disc of the back, for relief of back pain and related symptoms, which comprises: an aqueous solution of an effective dosage of cysteine, in combination with sodium Iothalamate present in a concentration of at least 10 mg. per ml. of solution, said formulation being free of proteolytic enzymes and having a generally neutral pH.
Claim 19
Dependent Claim
22 words
The formulation of claim 14 in which from 3 to 50 mg. of cysteine hydrochloride are present per ml. of said solution.
Claim 20
Dependent Claim
22 words
The formulation of claim 15 in which from 15 to 25 mg. of sodium Iothalamate are present per ml. of said solution.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |