US4055641A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating benign prostatic hypertrophy
Assignee: Richardson Vicks Inc
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Filing: 1976-05-10
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Granted: 1977-10-25
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Expires: 1996-05-10
Abstract
Abstract Compounds of the following general formula are useful in treating benign prostatic hypertrophy: ##STR1## wherein R is --CHO or --CH 2 OR 1 ; each of R 1 and R 2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R 3 is hydrogen; or R 2 and R 3 together form a double bond between the 17-position carbon atom and the oxygen atom.
Inventors
- 👤 Harvey D. Benson
- 👤 Joyce Francis Grunwell
- 👤 John O'Neal Johnston
- 👤 Vladimir Petrow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:39
CPC Classifications
C; C07; C07J; C07J1/00; C07J1/0003; C07J1/0011; C07J1/0018; C07J1/0022; C07J17/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
120 words
A method of treating benign prostatic hypertrophy in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula: ##STR9##wherein R is --CHO or --CH 2 OR 1 ; each of R 1 and R 2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein th alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R 3 is hydrogen; or R 2 and R 3 together form a double bond between the 17- position carbon atom and the oxygen atom.
Claim 2
Independent Claim
120 words
A method of treating benign prostatic hypertrophy in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula: ##STR9##wherein R is --CHO or --CH 2 OR 1 ; each of R 1 and R 2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein th alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R 3 is hydrogen; or R 2 and R 3 together form a double bond between the 17- position carbon atom and the oxygen atom.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the compound is administered in an amount of from 0.1 to 500 mg/kg.
Claim 4
Dependent Claim
11 words
The method of claim 2 wherein the compound is administered orally.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the compound is administered in an amount of from 0.1 to 250 mg/kg.
Claim 6
Dependent Claim
11 words
The method of claim 4 wherein the compound is administered orally.
Claim 7
Dependent Claim
11 words
The method of claim 4 wherein the compound is administered parenterally.
Claim 8
Dependent Claim
9 words
The method of claim 1 wherein R is --CHO.
Claim 9
Dependent Claim
26 words
The method of claim 7 wherein R 2 and R 3 together form a double bond between the 17- position carbon atom and the oxygen atom.
Claim 10
Dependent Claim
10 words
The method of claim 8 wherein the compound is 3,17-dioxoandrost-4-en-19-al.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein R is --CH 2 OR 1 .
Claim 12
Dependent Claim
26 words
The method of claim 10 wherein R 2 and R 3 together form a double bond between the 17- position carbon atom and the oxygen atom.
Claim 13
Dependent Claim
10 words
The method of claim 11 wherein the compound is 19-hydroxyandrost-4-en-3,17-dione.
References Cited (Backward Citations)
US3449381A
Cited
US3235573A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-24 | 1981-04-25 | 1981-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-24 | 1985-04-25 | 1985-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-24 | 1989-04-25 | 1989-10-25 | $7700.00 | Window Closed / Lapsed |