US4057616A
Expired / Lapsed
US
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Metal hydroxide scintigraphic agents and method of preparation
Assignee: Mallinckrodt Inc
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Filing: 1975-11-07
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Granted: 1977-11-08
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Expires: 1995-11-07
Abstract
Abstract Metal hydroxides such as Fe(OH) 2 , Fe(OH) 3 and Sn(OH) 2 are prepared in the form of spherical particles of uniform and controlled size suitable for tagging with a radioactive element such as technetium-99m. Aqueous suspensions of such tagged particles are useful in scintigraphy as lung scanning agents.
Inventors
- 👤 Robert G. Wolfangel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 06:39
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/1241; A61K51/1244; A61K51/1251; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
59 words
A method for preparing water-insoluble metal hydroxides in the form of substantially spherical particles having diameters between 10μ and 100μ which comprises converting a solution of a hydrolyzable salt of the said metal into an aerosol mist and directing the said mist into a vessel substantially filled with a stirred solution of a strong base and a wetting agent.
Claim 2
Independent Claim
59 words
A method for preparing water-insoluble metal hydroxides in the form of substantially spherical particles having diameters between 10μ and 100μ which comprises converting a solution of a hydrolyzable salt of the said metal into an aerosol mist and directing the said mist into a vessel substantially filled with a stirred solution of a strong base and a wetting agent.
Claim 3
Dependent Claim
26 words
A method as set forth in claim 1 wherein the metal hydroxide is selected from the group consisting of ferrous hydroxide, ferric hydroxide and stannous hydroxide.
Claim 4
Dependent Claim
28 words
A method as set forth in claim 1 wherein the mist is directed onto the surface of said stirred solution at an angle between approximately 10° and 90°.
Claim 5
Dependent Claim
29 words
A method as set forth in claim 1 wherein said stirred solution is rotating in the same direction as the direction in which the aerosol mist enters the solution.
Claim 6
Dependent Claim
17 words
A method as set forth in claim 2 wherein the strong base is an alkali metal hydroxide.
Claim 7
Dependent Claim
17 words
A method as set forth in claim 1 wherein the wetting agent is a lower aliphatic alcohol.
Claim 8
Dependent Claim
20 words
A method as set forth in claim 1 wherein the substantially spherical particles produced are thereafter tagged with a radionuclide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |