Patent JPS6412477A successfully refreshed from Google Patents.
US4057997A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sample preparation
Assignee: Applied Automation Inc
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Filing: 1976-03-31
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Granted: 1977-11-15
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Expires: 1996-03-31
Abstract
Abstract In the preparation of a sample to be subjected to chromatographic separation and analysis, dilution of a sample of material to be analyzed is accomplished by combining a flow containing the sample material with a diluting flow. The diluted sample material thus obtained is sampled and analyzed. In one preferred embodiment spent carrier fluid from the chromatographic separation column can be used as the diluting stream.
Inventors
- 👤 Craig S. Chandler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 13:49
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/04; G01N30/06
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
161 words
Apparatus comprising: fluid sample material supply means for providing a supply of fluid sample material; first, second, and third diluent conduit means for providing respective first, second, and third diluent fluid paths, each said diluent conduit means having an upstream end and a downstream end; diluent material supply means for providing a flow of diluent material to the upstream ends of said first and second diluent conduit means; first tee means for providing fluid communication among the downstream end of said first diluent conduit means, the downstream end of said second diluent conduit means, and the upstream end of said third diluent conduit means; means for injecting a preselected volume of sample material from said sample material supply means into said first diluent conduit means at a location intermediate of the upstream and downstream ends of said first diluent conduit means; and means for removing a preselected volume of material from said third diluent conduit means to provide a diluted sample.
Claim 2
Dependent Claim
161 words
Apparatus comprising: fluid sample material supply means for providing a supply of fluid sample material; first, second, and third diluent conduit means for providing respective first, second, and third diluent fluid paths, each said diluent conduit means having an upstream end and a downstream end; diluent material supply means for providing a flow of diluent material to the upstream ends of said first and second diluent conduit means; first tee means for providing fluid communication among the downstream end of said first diluent conduit means, the downstream end of said second diluent conduit means, and the upstream end of said third diluent conduit means; means for injecting a preselected volume of sample material from said sample material supply means into said first diluent conduit means at a location intermediate of the upstream and downstream ends of said first diluent conduit means; and means for removing a preselected volume of material from said third diluent conduit means to provide a diluted sample.
Claim 3
Dependent Claim
99 words
Apparatus in accordance with claim 1 wherein said diluent material supply means comprises: diluent reservoir means for maintaining a supply of diluent fluid therein; diluent supply conduit means for providing a flow of diluent material therethrough, said diluent supply conduit means having an upstream end and a downstream end, said upstream end thereof being in fluid communication with said diluent reservoir means; and second tee means for providing fluid communication among the upstream end of said first diluent conduit means, the upstream end of said second diluent conduit means, and the downstream end of said diluent supply conduit means.
Claim 4
Dependent Claim
51 words
Apparatus in accordance with claim 1 additionally comprising a chromatographic separation apparatus, wherein said means for removing a preselected volume of material from said third diluent conduit comprises means for injecting said preselected volume of material from said third diluent conduit into a carrier fluid stream of a chromatographic separation apparatus.
Claim 5
Dependent Claim
46 words
Apparatus in accordance with claim 3 wherein said chromatographic separation apparatus comprises an analyzer effluent conduit means for discharging carrier and sample material eluted through said chromatographic separation apparatus, and wherein said analyzer effluent conduit means is in fluid communication with said diluent material supply means.
Claim 6
Dependent Claim
99 words
Apparatus in accordance with claim 4 wherein said diluent material supply means comprises: diluent reservoir means for maintaining a supply of diluent fluid therein; diluent supply conduit means for providing a flow of diluent material therethrough, said diluent supply conduit means having an upstream end and a downstream end, said upstream end thereof being in fluid communication with said diluent reservoir means; and second tee means for providing fluid communication among the upstream end of said first diluent conduit means, the upstream end of said second diluent conduit means, and the downstream end of said diluent supply conduit means.
Claim 7
Dependent Claim
25 words
Apparatus in accordance with claim 5 wherein said diluent supply conduit means comprises pump means for providing flow impetus through said diluent supply conduit means.
Claim 8
Dependent Claim
94 words
Apparatus in accordance with claim 4 wherein said means for removing a preselected volume of material from said third diluent conduit comprises a sample valve means operatively connected in said third diluent conduit, means operatively associated with said third diluent conduit at a predetermined location upstream of said sample valve to detect the presence of said sample material in said third conduit at said predetermined location, and means responsive to said means to detect to operate said sample valve means in predetermined time relationship with the detection of sample material at said predetermined location.
Claim 9
Dependent Claim
37 words
Apparatus in accordance with claim 4 further comprising means for increasing the flow rate of fluid in said first diluent conduit means after the removal of said preselected volume of material from said third diluent conduit means.
Claim 10
Dependent Claim
94 words
Apparatus in accordance with claim 1 wherein said means for removing a preselected volume of material from said third diluent conduit comprises a sample valve means operatively connected in said third diluent conduit, means operatively associated with said third diluent conduit at a predetermined location upstream of said sample valve to detect the presence of said sample material in said third conduit at said predetermined location, and means responsive to said means to detect to operate said sample valve means in predetermined time relationship with the detection of sample material at said predetermined location.
Claim 11
Dependent Claim
37 words
Apparatus in accordance with claim 1 further comprising means for increasing the flow rate of fluid in said first diluent conduit means after the removal of said preselected volume of material from said third diluent conduit means.
Claim 12
Dependent Claim
105 words
A sampling method comprising: establishing a first diluent stream having a flow of a diluent fluid passing therethrough at a first flow rate; establishing a second diluent stream having a flow of said diluent fluid passing therethrough at a second flow rate, said second flow rate bearing a fixed relationship to said first flow rate; injecting a preselected volume of sample material into said first diluent stream; combining said first diluent stream and said second diluent stream to form a third diluent stream; and removing a representative preselected volume of fluid containing said sample material from said third diluent stream to provide a diluted sample.
Claim 13
Dependent Claim
105 words
A sampling method comprising: establishing a first diluent stream having a flow of a diluent fluid passing therethrough at a first flow rate; establishing a second diluent stream having a flow of said diluent fluid passing therethrough at a second flow rate, said second flow rate bearing a fixed relationship to said first flow rate; injecting a preselected volume of sample material into said first diluent stream; combining said first diluent stream and said second diluent stream to form a third diluent stream; and removing a representative preselected volume of fluid containing said sample material from said third diluent stream to provide a diluted sample.
Claim 14
Dependent Claim
55 words
A method in accordance with claim 11 wherein removing said representative preselected volume of fluid containing said sample material comprises removing said preselected volume of fluid containing sample material at a preselected location within said third diluent stream and at a preselected time following the injection of said sample material into said first diluent stream.
Claim 15
Dependent Claim
39 words
A method in accordance with claim 11 wherein said preselected time is within a period of time during which a representative, generally uniform concentration of said sample material is present at said preselected location within said third diluent stream.
Claim 16
Dependent Claim
71 words
A method in accordance with claim 4 wherein removing a representative preselected volume of fluid containing said sample material from said third diluent stream comprises injecting a preselected volume of fluid containing said sample material from said third diluent stream into the carrier fluid of a chromatographic carrier stream associated with a chromatographic separation means, and wherein said method additionally comprises passing said chromatographic carrier stream through a chromatographic separation column.
Claim 17
Dependent Claim
21 words
A method in accordance with claim 14 wherein said carrier fluid and said diluent fluid are of substantially the same composition.
Claim 18
Dependent Claim
33 words
A method in accordance with claim 15 additionally comprising using the effluent from said chromatographic carrier stream as at least a portion of the diluent material for said first and second diluent streams.
Claim 19
Dependent Claim
55 words
A method in accordance with claim 16 wherein removing said representative preselected volume of fluid containing said sample material comprises removing said preselected volume of fluid containing sample material at a preselected location within said third diluent stream and at a preselected time following the injection of said sample material into said first diluent stream.
Claim 20
Dependent Claim
39 words
A method in accordance with claim 17 wherein said preselected time is within a period of time during which a representative, generally uniform, concentration of said sample material is present at said preselected location within said third diluent stream.
Claim 21
Dependent Claim
28 words
A method in accordance with claim 18 additionally comprising filtering the material flowing through said third diluent stream upstream of said preselected location within said third diluent stream.
Claim 22
Dependent Claim
80 words
A method in accordance with claim 16 wherein removing said representative preselected volume of fluid containing said sample material comprises detecting the presence of sample material at a first preselected location within said third diluent stream and removing said preselected volume of fluid containing sample material at a second preselected location within said third diluent stream downstream of said first preselected location in predetermined time relationship with the detection of the presence of sample material at said first predetermined location.
Claim 23
Dependent Claim
35 words
A method in accordance with claim 16 further comprising increasing the flow rate of said first diluent stream after said representative preselected volume of fluid containing sample material is removed from said third diluent stream.
Claim 24
Dependent Claim
79 words
A method in accordance with claim 11 wherein removing said representative preselected volume of fluid containing said sample material comprises detecting the presence of sample material at a first preselected location within said third diluent stream and removing said preselected volume of fluid containing sample material at second preselected location within said third diluent stream downstream of said first preselected location in predetermined time relationship with the detection of the presence of sample material at said first predetermined location.
Claim 25
Dependent Claim
35 words
A method in accordance with claim 11 further comprising increasing the flow rate of said first diluent stream after said representative preselected volume of fluid containing sample material is removed from said third diluent stream.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |