US4058623A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prostaglandin-containing lyophilized powders
Assignee: Bayer Pharma AG
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Filing: 1976-03-22
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Granted: 1977-11-15
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Expires: 1996-03-22
Abstract
Abstract Lyophilized prostaglandin-containing powders are stabilized with tris(hydroxymethyl)-aminomethane hydrochloride.
Inventors
- 👤 Rolf-Rudiger Hoffmann
- 👤 Peter Fuchs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 22:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/30; A61K47/32; A61K9/00; A61K9/0012; A61K9/0019; A61P; A61P43/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
46 words
A storage-stable lyophilized prostaglandin composition comprising a prostaglandin compound and a decomposition-inhibiting quantity of tris (hydroxymethyl) aminomethane acid addition salts, said composition prior to being lyophilized having a pH of about 5-7, and the acid of said acid addition salts being other than said prostaglandin compound.
Claim 2
Dependent Claim
46 words
A storage-stable lyophilized prostaglandin composition comprising a prostaglandin compound and a decomposition-inhibiting quantity of tris (hydroxymethyl) aminomethane acid addition salts, said composition prior to being lyophilized having a pH of about 5-7, and the acid of said acid addition salts being other than said prostaglandin compound.
Claim 3
Dependent Claim
11 words
The composition of claim 1, which further contains an inert filler.
Claim 4
Dependent Claim
18 words
The composition of claim 1, comprising 1-1000 parts of tris(hydroxymethyl)aminomethane acid addition salts per part of prostaglandin compound.
Claim 5
Dependent Claim
18 words
The composition of claim 1, comprising 1-200 parts of tris(hydroxymethyl)aminomethane acid addition salts per part of prostaglandin compound.
Claim 6
Dependent Claim
13 words
The composition of claim 1, wherein the acid addition salt is the hydrochloride.
Claim 7
Dependent Claim
20 words
The composition of claim 3, which further contains up to 1000 parts of inert filler per part of prostaglandin compound.
Claim 8
Dependent Claim
18 words
The composition of claim 3, which further contains 1-200 parts of inert filler per part of prostaglandin compound.
Claim 9
Dependent Claim
11 words
The composition of claim 2, wherein the inert filler is polyvinylpyrrolidone.
Claim 10
Dependent Claim
15 words
The composition of claim 1, wherein the prostaglandin compound is a prostaglandin E 2 compound.
Claim 11
Dependent Claim
12 words
The composition of claim 1, wherein the prostaglandin compound is (5Z,13E)-(8R,11R,12R,15S)-11,15-dihydroxy-9-oxo-5,13-prostadienoic acid-(N-methanesulfonylamide).
Claim 12
Dependent Claim
13 words
The composition of claim 1, wherein the prostaglandin compound is 16-phenoxyprostaglandin-E 2 -methanesulfonamide.
Claim 13
Dependent Claim
49 words
A process for preparing the storage-stable, lyophilized composition of claim 1, comprising dissolving a prostaglandin compound and tris(hydroxymethyl)aminomethane in a solvent, bringing the pH of the solution to 5-7 by introduction of an acid other than said prostaglandin compound, filtering said solution, and lyophilizing the filtrate from said solution.
Claim 14
Dependent Claim
20 words
The process of claim 12, wherein the solvent is water or a mixture of water and a water-miscible, highlyvolatile solvent.
Claim 15
Dependent Claim
13 words
The process of claim 12, wherein a filler is dissolved in said solution.
Claim 16
Dependent Claim
10 words
The process of claim 12, wherein the filler is polyvinylpyrrolidone.
Claim 17
Dependent Claim
11 words
The process of claim 12, wherein the acid is hydrogen chloride.
Claim 18
Dependent Claim
37 words
An aqueous solution of a prostaglandin compound and a decomposition-inhibiting quantity of an acid addition salt of tris(hydroxymethyl)aminomethane, said solution having a pH of about 5-7, the acid of said acid salt being other than said prostaglandin.
Claim 19
Dependent Claim
37 words
An aqueous solution of a prostaglandin compound and a decomposition-inhibiting quantity of an acid addition salt of tris(hydroxymethyl)aminomethane, said solution having a pH of about 5-7, the acid of said acid salt being other than said prostaglandin.
Claim 20
Dependent Claim
15 words
An aqueous solution according to claim 17, said prostaglandin being a prostaglandin E 2 compound.
Claim 21
Dependent Claim
14 words
A solution according to claim 18 wherein said acid addition salt is a hydrochloride.
References Cited (Backward Citations)
US3904679A
Cited
US3954787A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |