US4066742A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tc-99m sulfur colloid radiopharmaceuticals
Assignee: Medi Physics Inc
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Filing: 1977-02-14
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Granted: 1978-01-03
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Expires: 1997-02-14
Abstract
Abstract A Tc-99m stannous sulfur colloid radiopharmaceutical having simplicity of formulation, improved stability and desirable small particle size as well as a method of preparation therefor are described. Also provided is a reagent suitable for the preparation of such radiopharmaceutical by the addition thereto of technetium-99m pertechnetate.
Inventors
- 👤 Michael David Garrett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:51
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/02; A61K51/025; A61K2123/00; Y; Y10; Y10S; Y10S516/00; Y10S516/924
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
146 words
A method for the preparation of a stannous sulfur colloid reagent suitable for the preparation of a size-stabilized Tc-99m-labeled radiopharmaceutical which comprises: a. adding a sufficient quantity of a 1 molar colloid of stannous chloride in sterile, pyrogen-free water to a predetermined quantity of distilled water to achieve a stannous chloride concentration in the final reagent of between about 0.5 and about 2.0 millimoles; b. adding to the mixture of step a) a sufficient quantity of 5% by weight aqueous solution of gelatin to achieve a gelatin concentration in the final reagent of between about 0.05% by weight and about 1.0% by weight; c. treating the mixture of step b) with hydrogen sulfide gas; d. purging the reagent formed in c) with nitrogen gas; e. filtering said reagent through a filter having openings of 0.45 micron; and f. aseptically sealing said reagent in a nitrogen-purged ampul.
Claim 2
Independent Claim
146 words
A method for the preparation of a stannous sulfur colloid reagent suitable for the preparation of a size-stabilized Tc-99m-labeled radiopharmaceutical which comprises: a. adding a sufficient quantity of a 1 molar colloid of stannous chloride in sterile, pyrogen-free water to a predetermined quantity of distilled water to achieve a stannous chloride concentration in the final reagent of between about 0.5 and about 2.0 millimoles; b. adding to the mixture of step a) a sufficient quantity of 5% by weight aqueous solution of gelatin to achieve a gelatin concentration in the final reagent of between about 0.05% by weight and about 1.0% by weight; c. treating the mixture of step b) with hydrogen sulfide gas; d. purging the reagent formed in c) with nitrogen gas; e. filtering said reagent through a filter having openings of 0.45 micron; and f. aseptically sealing said reagent in a nitrogen-purged ampul.
Claim 3
Dependent Claim
55 words
A method in accordance with claim 1 wherein the amount of said colloid of stannous chloride added is sufficient to achieve a stannous chloride concentration in the final reagent of about 1.0 millimole and the amount of said gelatin solution added is sufficient to achieve a concentration of 0.2% by weight in the final reagent.
Claim 4
Dependent Claim
40 words
A packaged reagent for preparing size-stabilized sulfur colloid consisting of an aqueous colloid of stannous sulfide additionally containing from about 0.05% by weight to about 1.0% by weight gelatin, based on the total reagent, aseptically enclosed in a nitrogen-purged ampule.
Claim 5
Dependent Claim
40 words
A packaged reagent for preparing size-stabilized sulfur colloid consisting of an aqueous colloid of stannous sulfide additionally containing from about 0.05% by weight to about 1.0% by weight gelatin, based on the total reagent, aseptically enclosed in a nitrogen-purged ampule.
Claim 6
Dependent Claim
23 words
A reagent in accordance with claim 3 wherein the concentration of said stannous sulfide is between from about 0.5 to about 2.0 millimoles.
Claim 7
Dependent Claim
28 words
A reagent in accordance with claim 3 wherein the concentration of said stannous sulfide is about 1 millimolar and the concentration of gelatin is about 0.2% by weight.
Claim 8
Dependent Claim
11 words
A radiopharmaceutical comprising the reagent of claim 3 labeled with technetium-99m.
Claim 9
Dependent Claim
30 words
A method of imaging the liver and spleen of a patient comprising intravenously injecting the patient with the radiopharmaceutical of claim 6 and then scintigraphically imaging the liver and spleen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-02 | 1981-07-04 | 1982-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-02 | 1985-07-04 | 1986-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-02 | 1989-07-04 | 1990-01-03 | $7700.00 | Window Closed / Lapsed |