US4067975A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of psoriasis with 6-aminonicotinamide and thionicotinamide
Assignee: Individual
•
Filing: 1975-08-04
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Granted: 1978-01-10
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Expires: 1995-08-04
Abstract
Abstract A treatment to alleviate the symptoms of psoriasis consisting of topical application of a cream, ointment or lotion containing as an active ingredient one or more of the following compounds: 6-aminonicotinamide, 6-carbamoylnicotinamide, 6-chloronicotinamide, 6-dimethylaminonicotinamide, 6-formylaminonicotinamide, 6-aminonicotinic acid, 6-aminonicotinic acid methyl ester, 6-hydroxy nicotinic acid, thionicotinamide, 2-aminopyrazinamide and 2-carbamoylpyrazinamide is disclosed. The therapeutic composition may include a single member of the above listed active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition, or a plurality thereof present in a preferred concentration range of from 0.01 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a cream, ointment, or a water or alcohol solution has been found to achieve from substantial to complete remissions of psoriasis in humans.
Inventors
- 👤 Ruey J. Yu
- 👤 Eugene J. Van Scott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/435; A61K31/44; A61K31/455; A61K31/56; A61K31/57
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
51 words
A method for alleviating the symptoms of psoriasis in a human suffering therefrom comprising: applying, topically, to involved areas of the human body an effective amount of a composition of 6-aminonicotinamide in a concentration of from 0.01 to 5 percent by weight of the total composition, in a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
51 words
A method for alleviating the symptoms of psoriasis in a human suffering therefrom comprising: applying, topically, to involved areas of the human body an effective amount of a composition of 6-aminonicotinamide in a concentration of from 0.01 to 5 percent by weight of the total composition, in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein 6-aminonicotinamide is present in a concentration of from 0.01 to about 2 percent.
Claim 4
Dependent Claim
21 words
The method of claim 1 wherein said carrier comprises a member selected from the group consisting of water, ethanol, and acetone.
Claim 5
Dependent Claim
21 words
The method of claim 1 wherein said carrier comprises a member selected from the group consisting of hydrophilic ointment and petrolatum.
Claim 6
Dependent Claim
45 words
A therapeutic composition for alleviating the symptoms of psoriasis in a human by topical application to involved areas of the human body comprising: 6-aminonicotinamide present in a concentration of from 0.01 to 5 percent, by weight, of the total composition in a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
45 words
A therapeutic composition for alleviating the symptoms of psoriasis in a human by topical application to involved areas of the human body comprising: 6-aminonicotinamide present in a concentration of from 0.01 to 5 percent, by weight, of the total composition in a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
24 words
The composition of claim 5 wherein 6-aminonicotinamide is present in a concentration of 0.01 to about 2 percent by weight of the total composition.
Claim 9
Dependent Claim
39 words
The composition of claim 5 further comprising a member selected from the group consisting of water, hydrochloric acid, ethanol, and acetone, said member present in a concentration of from 1 to 20 percent by volume of the total composition.
Claim 10
Dependent Claim
19 words
The composition of claim 7 wherein said member is present in a concentration of about 10 percent by volume.
Claim 11
Dependent Claim
19 words
The composition of claim 5 wherein said carrier is selected from the group consisting of petrolatum and hydrophilic ointment.
Claim 12
Dependent Claim
59 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 6.3 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.9 mls to 90 grams.
Claim 13
Dependent Claim
55 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 5 parts water and 4.9 parts ethanol, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.9 mls to 90 grams.
Claim 14
Dependent Claim
35 words
The composition of claim 5 wherein said carrier comprises a mixture of anhydrous ethanol and petrolatum, said ethanol and petrolatum being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 15
Dependent Claim
59 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 7 parts of a 1N HCl solution and 2 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 16
Dependent Claim
55 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 5 parts water and 4 parts acetone, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 17
Dependent Claim
59 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 5.8 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.4 mls to 90 grams.
Claim 18
Dependent Claim
59 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 6.1 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.7 mls to 90 grams.
Claim 19
Dependent Claim
76 words
The composition of claim 5 wherein said carrier comprises a mixture of a liquid and a water-in-oil lotion, said liquid comprising 7.2 parts of a 0.2N HCl solution, by volume, and said water-in-oil lotion comprises 10 parts mineral oil, 10 parts cottonseed oil, 5 parts isopropyl palmitate, 70 parts water, and 5 parts sorbitan sequioleate, by weight, said solvent and lotion being present in said composition in a volume-weight ratio of 7.2 mls to 92.6 grams.
Claim 20
Dependent Claim
20 words
The composition of claim 5 further comprising, as an additional ingredient of said composition, about 0.2 parts by weight hydrocortisone.
Claim 21
Dependent Claim
77 words
The composition of claim 18 wherein said carrier comprises a mixture of a liquid and a water-in-oil ointment, said liquid comprising 7.2 parts of a 0.2N HCl solution, by volume, said water-in-oil ointment comprising 10 parts mineral oil, 10 parts white petrolatum, 8 parts spermaceti, 2 parts lanolin, 60 parts water, and 6 parts sorbitan sequioleate, by weight, said solvent and ointment being present in said composition in a volume-weight ratio of 7.2 mls to 92.4 grams.
Claim 22
Independent Claim
51 words
A method for alleviating the symptoms of psoriasis in a human suffering therefrom comprising: applying, topically, to involved areas of the human body an effective amount of a composition of thionicotinamide in a concentration of from 0.01 to 5 percent by weight of the total composition, in a pharmaceutically acceptable carrier.
Claim 23
Independent Claim
51 words
A method for alleviating the symptoms of psoriasis in a human suffering therefrom comprising: applying, topically, to involved areas of the human body an effective amount of a composition of thionicotinamide in a concentration of from 0.01 to 5 percent by weight of the total composition, in a pharmaceutically acceptable carrier.
Claim 24
Dependent Claim
19 words
The method of claim 20 wherein thionicotinamide is present in a concentration of from 0.01 to about 2 percent.
Claim 25
Dependent Claim
21 words
The method of claim 20 wherein said carrier comprises a member selected from the group consisting of water, ethanol and acetone.
Claim 26
Dependent Claim
21 words
The method of claim 20 wherein said carrier comprises a member selected from the group consisting of hydrophilic ointment and petrolatum.
Claim 27
Dependent Claim
45 words
A therapeutic composition for alleviating the symptoms of psoriasis in a human by topical application to involved areas of the human body comprising: thionicotinamide present in a concentration of from 0.01 to 5 percent, by weight, of the total composition in a pharmaceutically acceptable carrier.
Claim 28
Dependent Claim
45 words
A therapeutic composition for alleviating the symptoms of psoriasis in a human by topical application to involved areas of the human body comprising: thionicotinamide present in a concentration of from 0.01 to 5 percent, by weight, of the total composition in a pharmaceutically acceptable carrier.
Claim 29
Dependent Claim
24 words
The composition of claim 24 wherein thionicotinamide is present in a concentration of 0.01 to about 2 percent by weight of the total composition.
Claim 30
Dependent Claim
39 words
The composition of claim 24 further comprising a member selected from the group consisting of water, hydrochloric acid, ethanol, and acetone, said member present in a concentration of from 1 to 20 percent by volume of the toal composition.
Claim 31
Dependent Claim
19 words
The composition of claim 24 wherein said member is present in a concentration of about 10 percent by volume.
Claim 32
Dependent Claim
19 words
The composition of claim 24 wherein said carrier is selected from the group consisting of petrolatum and hydrophilic ointment.
Claim 33
Dependent Claim
59 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 6.3 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.9 mls to 90 grams.
Claim 34
Dependent Claim
55 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 5 parts water and 4.9 parts ethanol, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.9 mls to 90 grams.
Claim 35
Dependent Claim
35 words
The composition of claim 24 wherein said carrier comprises a mixture of anhydrous ethanol and petrolatum, said ethanol and petrolatum being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 36
Dependent Claim
59 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 7 parts of a 1N HCl solution and 2 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 37
Dependent Claim
55 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 5 parts water and 4 parts acetone, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9 mls to 90 grams.
Claim 38
Dependent Claim
59 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 5.8 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.4 mls to 90 grams.
Claim 39
Dependent Claim
59 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and an ointment base, said liquid comprising 3.6 parts of a 0.2N HCl solution and 6.1 parts water, by volume, admixed with said ointment base, said liquid and ointment base being present in said composition in a volume-weight ratio of 9.7 mls to 90 grams.
Claim 40
Dependent Claim
75 words
The composition of claim 24 wherein said carrier comprises a mixture of a liquid and water-in-oil lotion, said liquid comprising 7.2 parts of a 0.2N HCl solution, by volume, and said water-in-oil lotion comprises 10 parts mineral oil, 10 parts cottonseed oil, 5 parts isopropyl palmitate, 70 parts water, and 5 parts sorbitan sesquioleate, by weight, said solvent and lotion being present in said composition in a volume-weight ratio of 7.2 mls to 92.6 grams.
Claim 41
Dependent Claim
20 words
The composition of claim 24 further comprising, as an additional ingredient of said composition, about 0.2 parts by weight hydrocortisone.
Claim 42
Dependent Claim
77 words
The composition of claim 37 wherein said carrier comprises a mixture of a liquid and a water-in-oil ointment, said liquid comprising 7.2 parts of a 0.2N HCl solution, by volume, said water-in-oil ointment comprising 10 parts mineral oil, 10 parts white petrolatum, 8 parts spermaceti, 2 parts lanolin, 60 parts water, and 6 parts sorbitan sequioleate, by weight, said solvent and ointment being present in said composition in a volume-weight ratio of 7.2 mls to 92.4 grams.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-09 | 1981-07-11 | 1982-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-09 | 1985-07-11 | 1986-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-09 | 1989-07-11 | 1990-01-10 | $7700.00 | Window Closed / Lapsed |