Pyrazolo [1,5-C]quinazoline derivatives and related compounds

Claim 1

A compound of the structure ##STR537## wherein R 1 and R 2 are the same or different, and R 1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, phenyl having an R 4 substituent, or ##STR538## R 2 is selected from the group consisting of ##STR539## hydrogen, lower alkyl, phenyl or phenyl having an R 2 substitutent, with the proviso that at least one of R 1 and R 2 is ##STR540## R 6 is selected from the group consisting of ##STR541## having 1 to 8 carbons in the alkyl group, ##STR542## having 1 to 8 carbons in the alkyl group or ##STR543## wherein phenyl includes unsubstituted phenyl, mono-, or di-lower-alkylphenyl, or halophenyl; R 3 is selected from the group consisting of hydrogen, lower alkyl, benzyl, phenyl, or phenyl having an R 4 sustituent; R 4 and R 5 are the same or different and are selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, lower alkanoyloxy of 1 to 4 carbons, nitro, benzyloxy, benzyloxy having a lower alkoxy, halogen, hydroxy, or trifluoromethyl substituent; R 7 and R 8 may be the same or different and are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbons, phenyl, phenyl having a lower alkoxy substituent, benzyl, or benzyl having a lower alkoxy substituent, or R 7 and R 8 taken together is a single cycloalkyl ring of 3 to 7 carbons; (CH 2 ) m and (CH 2 ) n represent straight chain alkylene radicals or mono- or di-alkyl substituted alkylene radicals wherein the alkyl group has 1 to 8 carbons, m and n are integers which represent the number of carbon atoms in the longest normal chains and may be the same or different and are 0 to 10, with the proviso that m + n ≦ 10, and physiologically acceptable salts thereof.