US4077952A
Expired / Lapsed
US
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Somatostatin analogs
Assignee: Wyeth LLC
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Filing: 1977-03-17
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Granted: 1978-03-07
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Expires: 1997-03-17
Abstract
Abstract Somatostatin analogs which contain L-Arg 4 -L-His 5 amino acids residues in place of the normally present L-Lys 4 -L-Asn 5 residues are disclosed. Other modifications of somatostatin are also disclosed. These compounds inhibit the release of pituitary growth hormone, glucagon, and insulin.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:29
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
52 words
A chemical compound of the structure: ##STR6## wherein A is hydrogen or the two A groups form a direct bond between the sulfur atoms; X is H, L-Ala-Gly, Gly-Gly, L-Ala-D-Ala, or Gly-Gly-Gly; X 1 is L-Trp or D-Tryp; X 2 is L-Cys or D-Cys; and the pharmacologically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
52 words
A chemical compound of the structure: ##STR6## wherein A is hydrogen or the two A groups form a direct bond between the sulfur atoms; X is H, L-Ala-Gly, Gly-Gly, L-Ala-D-Ala, or Gly-Gly-Gly; X 1 is L-Trp or D-Tryp; X 2 is L-Cys or D-Cys; and the pharmacologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein X is hydrogen.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 wherein X 1 is D-Trp.
Claim 5
Dependent Claim
16 words
A compound according to claim 1 wherein X 1 is D-Trp and X 2 is L-Cys.
Claim 6
Dependent Claim
8 words
The compound of claim 1 which is: ##STR7##
Claim 7
Dependent Claim
8 words
The compound of claim 1 which is: ##STR8##
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-06 | 1981-09-05 | 1982-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-06 | 1985-09-05 | 1986-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-06 | 1989-09-05 | 1990-03-07 | $7700.00 | Window Closed / Lapsed |