US4079127A
Expired / Lapsed
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Thymosin alpha 1
Assignee: Sciclone Pharmaceuticals LLC
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Filing: 1977-02-08
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Granted: 1978-03-14
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Expires: 1997-02-08
Abstract
Abstract The amino acid sequence of a biologically active polypeptide hormone isolated from calf thymus termed thymosin alpha 1 has been determined. Thymosin alpha 1 is a heat stable acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells).
Inventors
- 👤 Allan L. Goldstein
- 👤 Teresa L. K. Low
- 👤 Chun-Yen Lai
- 👤 Su-Sun Wang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:42
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/57581; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
36 words
Thymosin α 1 being a polypeptide essentially free of other thymic polypeptides and having the following amino acid sequence: (N-acetyl)-Ser-Asp-Ala-Ala-Val.sup.5 -Asp-Thr-Ser-Ser-Glu.sup.10 -He-Thr-Thr-Lys-Asp.sup.15 -Leu-Lys-Glu-Lys-Lys.sup.20 -Glu-Val-Val-Glu-Glu.sup.25 -Ala-Glu-Asn-OH and the pharmaceutically acceptable acid addition salts or base salts thereof.
Claim 2
Dependent Claim
36 words
Thymosin α 1 being a polypeptide essentially free of other thymic polypeptides and having the following amino acid sequence: (N-acetyl)-Ser-Asp-Ala-Ala-Val.sup.5 -Asp-Thr-Ser-Ser-Glu.sup.10 -He-Thr-Thr-Lys-Asp.sup.15 -Leu-Lys-Glu-Lys-Lys.sup.20 -Glu-Val-Val-Glu-Glu.sup.25 -Ala-Glu-Asn-OH and the pharmaceutically acceptable acid addition salts or base salts thereof.
Claim 3
Independent Claim
30 words
A method for reconstituting immune functions in thymic deprived or immunodeprived warm blooded mammals which method comprises administering to said mammal an immunopotentiating effective amount of thymosin α 1 .
Claim 4
Independent Claim
30 words
A method for reconstituting immune functions in thymic deprived or immunodeprived warm blooded mammals which method comprises administering to said mammal an immunopotentiating effective amount of thymosin α 1 .
Claim 5
Dependent Claim
26 words
The method of claim 2 wherein a daily dosage in the range of from about 1 to 100 μg/kg of body weight per day is administered.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-13 | 1981-09-12 | 1982-03-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-13 | 1985-09-12 | 1986-03-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-13 | 1989-09-12 | 1990-03-14 | $7700.00 | Window Closed / Lapsed |