US4088757A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4'Alpha- and 4'beta-amino-4'-desoxyoleandrins, and pharmaceutical composition containing same
Assignee: BEIERSDORF HAFTNG A CORP OF GERMANY GmbH
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Filing: 1977-01-13
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Granted: 1978-05-09
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Expires: 1997-01-13
Abstract
Abstract The present invention relates to 4' amino-4' desoxy-oleandrins of the following formula (I) ##STR1## in which R 1 and R 2 may be the same or different and represent hydrogen or a lower alkyl group with 1 to 4 carbon atoms or R 1 and R 2 together with the nitrogen atom form a pyrrolidino, piperidino, or morpholino radical; as well as the physiologically compatible acid addition salts thereof. These compounds possess positive inotropic cardiac activity and are useful in cases of renal insufficiency.
Inventors
- 👤 Rudolf Petersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 03:58
CPC Classifications
C; C07; C07J; C07J41/00; C07J41/0033; C07J41/0055; A; A61; A61P; A61P9/00; A61P9/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
63 words
4'-alpha- and 4'beta-amino-4'-desoxy-oleandrins of the formula: ##STR4## wherein R 1 and R 2 , which may be the same or different, are individually selected from the group consisting of hydrogen, or a lower alkyl group with 1-4 carbon atoms, or R 1 and R 2 together with the nitrogen atom form pyrrolidino, piperidino, or morpholino; and the physiologically compatible acid addition salts thereof.
Claim 2
Dependent Claim
63 words
4'-alpha- and 4'beta-amino-4'-desoxy-oleandrins of the formula: ##STR4## wherein R 1 and R 2 , which may be the same or different, are individually selected from the group consisting of hydrogen, or a lower alkyl group with 1-4 carbon atoms, or R 1 and R 2 together with the nitrogen atom form pyrrolidino, piperidino, or morpholino; and the physiologically compatible acid addition salts thereof.
Claim 3
Dependent Claim
15 words
The compound as recited in claim 1 wherein R 1 and R 2 are hydrogen.
Claim 4
Dependent Claim
17 words
The compound as recited in claim 1 wherein R 1 is hydrogen and R 2 is ethyl.
Claim 5
Dependent Claim
17 words
The compound as recited in claim 1 wherein R 1 is methyl and R 2 is hydrogen.
Claim 6
Dependent Claim
15 words
The compound as recited in claim 1 wherein R 1 and R 2 are methyl.
Claim 7
Dependent Claim
21 words
A pharmaceutical composition containing an effective amount of at least one 4'-amino-4'desoxy-oleandrin according to claim 1 and a physiologically compatible substance.
References Cited (Backward Citations)
US3914213A
Cited
US3898331A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-08 | 1981-11-07 | 1982-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-08 | 1985-11-07 | 1986-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-08 | 1989-11-07 | 1990-05-09 | $7700.00 | Window Closed / Lapsed |