US4090849A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic device and manufacture thereof
Assignee: General Electric Co
•
Filing: 1976-12-20
•
Granted: 1978-05-23
•
Expires: 1996-12-20
Abstract
Abstract Clinically useful diagnostic devices are prepared from commercially available metal sheet stock by a sequence of steps. The metal is one of a type on the surface of which a tenacious oxide layer can be produced. Steps in the preparation include roughening surface area of the bulk metal with pits on a fine scale to render that surface area of the metal non-specularly reflecting, chemically etching the surface area to produce some first preselected measure of reflectivity, anodizing the surface area to produce a dull, non-specularly reflecting oxide surface having a second preselected degree of reflectivity and applying a layer of protein over this dull surface area. The preferred metal is titanium and the reflectivity of the modified surface area is selected dependent on the immunological reaction being detected.
Inventors
- 👤 William A. Healy
- 👤 William J. Ward, III
- 👤 David A. Vermilyea
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:40
CPC Classifications
A; A61; A61B; A61B10/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; G01N33/553; Y; Y10; Y10S; Y10S436/00; Y10S436/805; Y10S436/807; Y10S436/809
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
138 words
A process for the production of a diagnostic device useful for detecting the presence or absence of select biological particles in a liquid sample comprising the steps of: roughening surface area on a bulk metal substrate to render said surface area non-specularly reflecting, the metal having the property of enabling the formation of a tenacious oxide layer on the surface thereof; chemically etching said surface area to yield therefor a first preselected value of reflectivity; oxidizing said surface area to produce thereon an oxide layer having a thickness in the range of from about 100 Angstroms to about 500 Angstroms and to change said first preselected value of reflectivity to a second and larger preselected value of reflectivity, said oxide layer being non-specularly reflecting; and applying a layer of protein over at least part of said oxide layer.
Claim 2
Dependent Claim
138 words
A process for the production of a diagnostic device useful for detecting the presence or absence of select biological particles in a liquid sample comprising the steps of: roughening surface area on a bulk metal substrate to render said surface area non-specularly reflecting, the metal having the property of enabling the formation of a tenacious oxide layer on the surface thereof; chemically etching said surface area to yield therefor a first preselected value of reflectivity; oxidizing said surface area to produce thereon an oxide layer having a thickness in the range of from about 100 Angstroms to about 500 Angstroms and to change said first preselected value of reflectivity to a second and larger preselected value of reflectivity, said oxide layer being non-specularly reflecting; and applying a layer of protein over at least part of said oxide layer.
Claim 3
Dependent Claim
41 words
The process recited in claim 1 wherein the first preselected value of reflectivity is comparable to a value in the range of from about 0.30 to about 0.50 density units as measured on a Macbeth RD-100 densitometer using a visual filter.
Claim 4
Dependent Claim
29 words
The process recited in claim 3 wherein the roughening is in the form of pits, the span and depth of which are about 70,000 Angstroms or less in dimension.
Claim 5
Dependent Claim
22 words
The process recited in claim 1 wherein the metal is selected from the group consisting of titanium, tantalum, niobium, zirconium, and bismuth.
Claim 6
Dependent Claim
14 words
The process recited in claim 1 wherein the oxide layer is produced by anodizing.
Claim 7
Dependent Claim
17 words
The process recited in claim 5 wherein the anodizing step is conducted in an ammonium pentaborate solution.
Claim 8
Dependent Claim
41 words
The process recited in claim 1 wherein the second preselected value of reflectivity is comparable to a value in the range of from about 0.50 to about 0.85 density units as measured on a Macbeth RD-100 densitometer using a visual filter.
Claim 9
Dependent Claim
35 words
The process recited in claim 1 wherein the chemical etching is conducted in an acid bath, the content of which includes at least two acids selected from the group consisting of hydrofluoric, nitric and sulfuric.
Claim 10
Dependent Claim
26 words
The process recited in claim 1 wherein the thickness of the oxide layer is in the range of from about 250 Angstroms to about 300 Angstroms.
Claim 11
Dependent Claim
14 words
The process recited in claim 1 wherein the protein is an antigenically active material.
Claim 12
Dependent Claim
10 words
A diagnostic device prepared by the process of claim 1.
References Cited (Backward Citations)
US4054646A
Cited
US3853467A
Cited
US3926564A
Cited
US3979509A
Cited
US4041146A
Cited
US3979184A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-22 | 1981-11-21 | 1982-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-22 | 1985-11-21 | 1986-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-22 | 1989-11-21 | 1990-05-23 | $7700.00 | Window Closed / Lapsed |