US4100152A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptides
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1977-03-16
•
Granted: 1978-07-11
•
Expires: 1997-03-16
Abstract
Abstract A novel peptide of the formula: ##STR1## wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is ##STR2## X is --S-- or --(CH 2 ) n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.
Inventors
- 👤 Masahiko Fujino
- 👤 Osamu Nishimura
- 👤 Yuji Nagawa
- 👤 Naohisa Fukuda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:31
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33; A; A61; A61P; A61P25/00; A61P25/26; A61P5/00; C07D279/00; C07D279/10; C07D279/12; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
79 words
A member selected from the group consisting of a compound of the formula ##STR11## wherein A represents hydrogen, alkyl of up to 10 carbon atoms, aralkyl of up to 10 carbon atoms, alkoxyalkyl of up to 9 carbon atoms, hydroxyalkyl of up to 9 carbon atoms or alkoxy of up to 9 carbon atoms, R represents ##STR12## X represents --S-- or --(CH 2 ) n -- wherein n is 1 or 2, and a pharmacologically acceptable acid salt thereof.
Claim 2
Dependent Claim
79 words
A member selected from the group consisting of a compound of the formula ##STR11## wherein A represents hydrogen, alkyl of up to 10 carbon atoms, aralkyl of up to 10 carbon atoms, alkoxyalkyl of up to 9 carbon atoms, hydroxyalkyl of up to 9 carbon atoms or alkoxy of up to 9 carbon atoms, R represents ##STR12## X represents --S-- or --(CH 2 ) n -- wherein n is 1 or 2, and a pharmacologically acceptable acid salt thereof.
Claim 3
Dependent Claim
19 words
A compound according to claim 1 wherein R and other constituent amino acid residues are all of the L-configuration.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 wherein the compound is L-2-oxo-tetrahydrofuran-5-carbonyl-L-histidyl-L-prolinamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-10 | 1982-01-09 | 1982-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-10 | 1986-01-09 | 1986-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-10 | 1990-01-09 | 1990-07-11 | $7700.00 | Window Closed / Lapsed |