US4100920A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for transferring microorganisms through the skin barrier
Assignee: Individual
•
Filing: 1976-08-19
•
Granted: 1978-07-18
•
Expires: 1996-08-19
Abstract
Abstract Method and system for transferring microorganisms through the skin barrier are described. The system comprises a pair of electrodes connected to a source of continuous current, a nutrient solution containing microorganisms and an impregnating spongy support located between at least one of the electrodes and the skin barrier. The microorganisms in the nutrient solution pass through the skin barrier under the action of an electrical field created by the electrodes. The method has application in the immunological treatment of tumorous diseases by means of Immuno-B.C.G.
Inventors
- 👤 Jacqueline Marie George Juliette Le Goaster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:16
CPC Classifications
A; A61; A61N; A61N2/00; A61M; A61M37/00; A61N1/00; A61N1/18; A61N1/20; A61N1/30
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
65 words
A method for transferring microorganisms through the skin barrier of a patient comprising the steps of exposing the microorganisms outside and in contact with the skin barrier to an electrical field of an intensity less than that which causes discomfort to the patient but sufficient to casue transfer of the microorganisms, and maintaining said exposure for a time sufficient for effective transfer of the microorganisms.
Claim 2
Independent Claim
65 words
A method for transferring microorganisms through the skin barrier of a patient comprising the steps of exposing the microorganisms outside and in contact with the skin barrier to an electrical field of an intensity less than that which causes discomfort to the patient but sufficient to casue transfer of the microorganisms, and maintaining said exposure for a time sufficient for effective transfer of the microorganisms.
Claim 3
Dependent Claim
42 words
A method according to claim 1 further comprising before the step of exposing, the steps of placing the microorganisms in a nutrient medium containing elements responsive to the action of an electrical field, and applying the nutrient medium to the skin barrier.
Claim 4
Dependent Claim
11 words
A method according to claim 1 wherein the microorganisms are Immuno-B.C.G.
Claim 5
Dependent Claim
37 words
A method according to claim 1 wherein the electrical field is applied to a portion of skin barrier of about 5 × 5 cm and the intensity of the current is from about 1 to 2 mA.
Claim 6
Dependent Claim
19 words
A method according to claim 4 wherein the electrical field is applied for about 10 to about 15 minutes.
Claim 7
Dependent Claim
21 words
A method according to claim 1 wherein the electrical field is applied in a direction substantially perpendicular to the skin barrier.
Claim 8
Dependent Claim
20 words
A method according to claim 6 wherein the said electrical field is directed towards the outside of the skin barrier.
Claim 9
Dependent Claim
20 words
A method according to claim 7, for the immunological treatment of tumorous diseases, wherein the microorganisms used are immunity-adjuvant substances.
Claim 10
Independent Claim
100 words
A system for transferring microorganisms through the skin barrier comprising a pair of electrodes, a source of continuous current, an electrical connection between said source and said electrodes, a nutrient solution containing the said microorganisms, the said nutrient solution being adapted to be applied to the skin barrier, and the said electrodes being adapted to be arranged against the skin barrier, at least one of the electrodes being adapted to be arranged upon the part of the skin barrier to which is applied the nutrient solution containing the said microorganisms during use, said at least one electrode containing said solution.
Claim 11
Independent Claim
100 words
A system for transferring microorganisms through the skin barrier comprising a pair of electrodes, a source of continuous current, an electrical connection between said source and said electrodes, a nutrient solution containing the said microorganisms, the said nutrient solution being adapted to be applied to the skin barrier, and the said electrodes being adapted to be arranged against the skin barrier, at least one of the electrodes being adapted to be arranged upon the part of the skin barrier to which is applied the nutrient solution containing the said microorganisms during use, said at least one electrode containing said solution.
Claim 12
Dependent Claim
51 words
The system according to claim 9 wherein a spongy supporting element is impregnated with the said nutrient solution containing the said microorganisms, the said element contacting said at least one of the electrodes and being adapted to be interposed between said at least one electrode and the skin barrier during use.
Claim 13
Dependent Claim
25 words
The system according to claim 9 further comprising a retaining element supporting said electrodes and adapted to hold the electrodes firmly against the skin barrier.
Claim 14
Dependent Claim
82 words
The system according to claim 11 wherein said retaining element is in the form of a strip adapted to be wrapped around a patient's limb, the said electrodes being mounted upon the same face of the said strip, said face being adapted to be adjacent to the skin barrier during use, and the said source of current being in the form of a battery attached to the said strip, the system being portable and self-contained, and being easily operated by the patient.
Claim 15
Dependent Claim
23 words
The system according to claim 12 further comprising controlling means for controlling the intensity of the current supplied by the source of power.
Claim 16
Dependent Claim
17 words
The system according to claim 13 wherein the controlling means is mounted upon the said wrap-around strip.
Claim 17
Independent Claim
122 words
A system for transferring Immuno-B.C.G. through the skin barrier for the immunological treatment of tumorous diseases comprising a device comprising a pair of electrodes, a source of continuous current, and an electrical connection between said source and said electrodes, and at least a unit dose of Immuno-B.C.G. including a nutrient solution containing Koch bacilli, said unit dose being adapted to be applied to the skin barrier, and the said electrodes being adapted to be arranged against the skin barrier, the electrode connected to the negative terminal of the source of continuous current contacting the unit dose and being adapted to be arranged upon the part of the skin barrier to which a unit dose of Immuno-B.C.G is to be applied, during used.
Claim 18
Independent Claim
122 words
A system for transferring Immuno-B.C.G. through the skin barrier for the immunological treatment of tumorous diseases comprising a device comprising a pair of electrodes, a source of continuous current, and an electrical connection between said source and said electrodes, and at least a unit dose of Immuno-B.C.G. including a nutrient solution containing Koch bacilli, said unit dose being adapted to be applied to the skin barrier, and the said electrodes being adapted to be arranged against the skin barrier, the electrode connected to the negative terminal of the source of continuous current contacting the unit dose and being adapted to be arranged upon the part of the skin barrier to which a unit dose of Immuno-B.C.G is to be applied, during used.
Claim 19
Dependent Claim
57 words
The system according to claim 15 further comprising a spongy supporting element and wherein the said unit down impregnates said spongy supporting element, the said element contacting the electrode connected to the negative terminal and being adapted to be placed between the electrode connected to the negative terminal of the source of current and the skin barrier.
Claim 20
Independent Claim
68 words
A method for transferring Koch bacilli, maintained in a supporting medium, through the skin barrier of a patient comprising the steps of applying the Koch bacilli, with the supporting medium, to the skin barrier, and exposing the Koch bacilli to the action of an electrical field of sufficient intensity to cause transfer of the Koch bacilli and for a time sufficient to effect transfer of the Koch bacilli.
Claim 21
Independent Claim
68 words
A method for transferring Koch bacilli, maintained in a supporting medium, through the skin barrier of a patient comprising the steps of applying the Koch bacilli, with the supporting medium, to the skin barrier, and exposing the Koch bacilli to the action of an electrical field of sufficient intensity to cause transfer of the Koch bacilli and for a time sufficient to effect transfer of the Koch bacilli.
Claim 22
Independent Claim
110 words
A system for transferring an immunity-adjuvant, containing Koch bacilli, through the skin barrier, for the immunological treatment of tumorous diseases comprising a pair of electrodes, a source of continuous current, and an electrical connection between said source and said electrodes, at least a unit dose of the immunity-adjuvant consisting of a nutrient solution containing Koch bacilli, said unit dose being adapted to be applied to the skin barrier, and the electrode connected to the negative terminal of the source of continuous current contacting the Koch bacilli and being adapted to be arranged upon the part of the skin barrier to which said unit dose is to be applied during use.
Claim 23
Independent Claim
110 words
A system for transferring an immunity-adjuvant, containing Koch bacilli, through the skin barrier, for the immunological treatment of tumorous diseases comprising a pair of electrodes, a source of continuous current, and an electrical connection between said source and said electrodes, at least a unit dose of the immunity-adjuvant consisting of a nutrient solution containing Koch bacilli, said unit dose being adapted to be applied to the skin barrier, and the electrode connected to the negative terminal of the source of continuous current contacting the Koch bacilli and being adapted to be arranged upon the part of the skin barrier to which said unit dose is to be applied during use.
References Cited (Backward Citations)
US2784715A
Cited
US3025858A
Cited
US3122137A
Cited
US3289671A
Cited
US3618601A
Cited
US3991755A
Cited
US3964477A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |