US4101650A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pepstatin floating minicapsules
Assignee: Microbial Chemistry Research Foundation
•
Filing: 1977-04-06
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Granted: 1978-07-18
•
Expires: 1997-04-06
Abstract
Abstract Increased duration of inhibition of secretion of pepsin in man by oral administration of pepstatin is achieved by the use of a formulation in which pepstatin is coated on very small granules of sodium bicarbonate to form floating minicapsules.
Inventors
- 👤 Hamao Umezawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0065; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; Y; Y10; Y10S; Y10S530/00; Y10S530/86
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
46 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 2
Dependent Claim
46 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 3
Dependent Claim
67 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 4
Dependent Claim
67 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 5
Dependent Claim
63 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 6
Dependent Claim
63 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 7
Dependent Claim
83 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 8
Dependent Claim
83 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 9
Dependent Claim
72 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 10
Dependent Claim
72 words
A composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 11
Dependent Claim
83 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 12
Dependent Claim
83 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 13
Dependent Claim
104 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 14
Dependent Claim
104 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 15
Dependent Claim
100 words
The process of reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 16
Dependent Claim
100 words
The process of reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 17
Dependent Claim
120 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the rage of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 18
Dependent Claim
120 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the rage of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 19
Dependent Claim
109 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 20
Dependent Claim
109 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount effective to cause said reduction of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 21
Dependent Claim
86 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. peptstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 22
Dependent Claim
86 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. peptstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin.
Claim 23
Dependent Claim
107 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 24
Dependent Claim
107 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 25
Dependent Claim
103 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 26
Dependent Claim
103 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight of about five times the weight of said pepstatin.
Claim 27
Dependent Claim
123 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 28
Dependent Claim
123 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with at least one conventional solubilizing diluent and at least one water-soluble and solvent-soluble binder, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 29
Dependent Claim
112 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
Claim 30
Dependent Claim
112 words
The process for reducing the secretion of pepsin by the human stomach which comprises the oral administration in a patient being treated for a gastric or duodenal ulcer of an amount containing 50 to 200 mgm. pepstatin per dose of a composition in oral dosage form comprising minicapsules having a diameter in the range of 0.1 to 2 mm. in which the center comprises a granule of sodium bicarbonate admixed with lactose and polyvinylpyrrolidone, said granule being coated with a conventional water-soluble, film-coating agent and said center being coated with pepstatin, said sodium bicarbonate being present in a weight in the range of two to 10 times the weight of said pepstatin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
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