US4115418A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
Assignee: Government of the United States of America
•
Filing: 1976-09-02
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Granted: 1978-09-19
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Expires: 1996-09-02
Abstract
Abstract Organoplatinum complexes having antineoplastic activity against the L1210 mouse leukemia test system and having sufficient water-solubility for use in aqueous i.v. fluids. The organoplatinum complexes include malonato (1,2-diaminocyclohexane) platinum (II), hydroxymalonato (1,2-diaminocyclohexane) platinum (II), dinitrato (1,2-diaminocyclohexane) platinum (II), sulfato (1,2-diaminocyclohexane) platinum (II), and hydroxonitrato (1,2-diaminocyclohexane) platinum (II).
Inventors
- 👤 Glen Roy Gale
- 👤 Sandra Jan Meischen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 12:00
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
63 words
An organoplatinum complex having the formula ##STR11## wherein X is a monodentate anionic ligand selected from the group consisting of -- ONO 2 and ##STR12## or together with Y a bidentate anionic ligand of the formula ##STR13## when X is -- ONO 2 , Y is -- ONO 2 or -- OH; and when X is ##STR14## Y is -- OH 2 .sup.(+).
Claim 2
Dependent Claim
63 words
An organoplatinum complex having the formula ##STR11## wherein X is a monodentate anionic ligand selected from the group consisting of -- ONO 2 and ##STR12## or together with Y a bidentate anionic ligand of the formula ##STR13## when X is -- ONO 2 , Y is -- ONO 2 or -- OH; and when X is ##STR14## Y is -- OH 2 .sup.(+).
Claim 3
Dependent Claim
12 words
The organoplatinum complex of claim 1, consisting of hydroxymalonato (1,2-diaminocyclohexane) platinum (II).
Claim 4
Dependent Claim
12 words
The organoplatinum complex of claim 1, consisting of dinitrato (1,2-diaminocyclohexane) platinum (II).
Claim 5
Dependent Claim
12 words
The organoplatinum complex of claim 1, consisting of sulfato (1,2-diaminocyclohexane) platinum (II).
Claim 6
Dependent Claim
12 words
The organoplatinum complex of claim 1, consisting of hydroxonitrato (1,2-diaminocyclohexane) platinum (II).
References Cited (Backward Citations)
US3892790A
Cited
US3904663A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |