US4137246A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluorinated aromatic polyenes
Assignee: Hoffmann La Roche Inc
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Filing: 1977-06-24
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Granted: 1979-01-30
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Expires: 1997-06-24
Abstract
Abstract Compounds represented by the formula <IMAGE> wherein R1, R2 and R3 are lower alkyl, R4 is lower alkoxy, R6 and R8 are methyl or trifluoro methyl, R9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R5, R7, R10, R11 R12 and R13 are hydrogen or fluorine with the proviso that at least one of R5, R7, R10, R11, R12 or R13 is fluorine or at least one of R6 or R8 is trifluoro methyl, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF USEFUL AS ANTITUMOR AGENTS ARE DISCLOSED.
Inventors
- 👤 Ka-Kong Chan
- 👤 Beverly A. Pawson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:13
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07C; C07C45/00; C07C45/26; C07C45/27; C07C45/29; C07C45/292; C07C45/298; C07C45/31; C07C45/41; C07C45/45; C07C45/61; C07C45/67; C07C45/68; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006; C07F9/4015; C07F9/54; C07F9/5442
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
98 words
A compound represented by the formula ##STR38## wherein R 1 , R 2 and R 3 are lower alkyl, R 4 is lower alkoxy, R 6 and R 8 are methyl or trifluoro methyl, R 9 is alkoxycarbonyl, lower alkenoxycarbonyl and lower alkynoxycarbonyl; R 5 , R 7 , R 10 , R 12 and R 13 are hydrogen or fluorine with the proviso that at least one of R 5 , R 7 , R 10 , R 12 or R 13 is fluorine or at least one of R 6 or R 8 is trifluoro methyl.
Claim 2
Dependent Claim
98 words
A compound represented by the formula ##STR38## wherein R 1 , R 2 and R 3 are lower alkyl, R 4 is lower alkoxy, R 6 and R 8 are methyl or trifluoro methyl, R 9 is alkoxycarbonyl, lower alkenoxycarbonyl and lower alkynoxycarbonyl; R 5 , R 7 , R 10 , R 12 and R 13 are hydrogen or fluorine with the proviso that at least one of R 5 , R 7 , R 10 , R 12 or R 13 is fluorine or at least one of R 6 or R 8 is trifluoro methyl.
Claim 3
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-2-fluoro-3,7-dimethyl-2(Z),4(E),6(E),8(E)-nonatetraenoic acid ethyl ester.
Claim 4
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-2-fluoro-3,7-dimethyl-2(Z),4(E),6(Z),8(E)-nonatetraenoic acid ethyl ester.
Claim 5
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-6-fluoro-3,7-dimethyl-2(E),4(E),6(Z),8(E)-nonatetraenoic acid methyl ester.
Claim 6
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-6-fluoro-3,7-dimethyl-2(Z),4(E),6(Z),8(E)-nonatetraenoic acid methyl ester.
Claim 7
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-6-fluoro-3,7-dimethyl-2(E),4(E),6(E),8(E)-nonatetraenoic acid methyl ester.
Claim 8
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-4-fluoro-3,7-dimethyl-2(E),4(E),6(E),8(E)-nonatetraenoic acid ethyl ester.
Claim 9
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-4-fluoro-3,7-dimethyl-2(E),4(Z),6(E),8(E)-nonatetraenoic acid ethyl ester.
Claim 10
Dependent Claim
10 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-b 7-trifluoromethyl-2(E),4(E),6(E),8(E)-nonatetraenoic acid methyl ester.
Claim 11
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-8-fluoro-3,7-dimethyl-2(E),4(E),6(E),8(Z)-nonatetraenoic acid methyl ester.
Claim 12
Dependent Claim
9 words
The compound of claim 1, 9-(4-methoxy-2,3,6-trimethylphenyl)-3-trifluoromethyl-7-methyl-2(E),4(E),6(E),8(E)-nonatetraenoic acid ethyl ester.
Claim 13
Dependent Claim
7 words
The compound of claim 1, methyl 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-5-fluoro-2(E),4(Z),6(Z,E),8(E)-nonatetraenoate.
Claim 14
Dependent Claim
7 words
The compound of claim 1, ethyl 2(E),4(E),6(E),8(Z)-3,7-dimethyl-9-fluoro-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate.
Claim 15
Dependent Claim
7 words
The compound of claim 1, ethyl 2(E),6(E),8(E)-3,7-dimethyl-9-fluoro-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate.
Claim 16
Dependent Claim
7 words
The compound of claim 1, ethyl 2(E,Z),4(Z),6(E),8(E)-2,4-difluoro-3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate.
Claim 17
Dependent Claim
7 words
The compound of claim 1, ethyl 2(Z),4(E),6(Z),8(E)-2,6-difluoro-3,7-dimethyl-9-(4-methoxy-2,3,6trimethylphenyl)-nonatetraenoate.
Claim 18
Dependent Claim
7 words
The compound of claim 1, ethyl 2(E),4(Z),6(Z),8(E)-3,7-dimethyl-4,6-difluoro-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |