US4140760A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions for use in the suppression of gastric reflux
Assignee: COLMAN PRODUCTS Ltd
•
Filing: 1977-04-01
•
Granted: 1979-02-20
•
Expires: 1997-04-01
Abstract
Abstract A pharmaceutical composition for the suppression of gastric reflux comprises a low viscosity grade sodium alginate, from 0.16 to 2.60 parts by weight of sodium bicarbonate per part by weight of sodium alginate and from 0.10 to 1.04 parts by weight of calcium carbonate per part by weight of sodium alginate. These compositions may be presented in the form of dry powders which can be admixed with water to provide a palatable liquid preparation. However, preferably the compositions are presented in liquid form and a particularly preferred liquid composition comprises an aqueous medium containing 4.0 to 6.0% weight/volume of a low viscosity grade sodium alginate, 2.0 to 3.5% weight/volume of sodium bicarbonate, 1.2 to 2.0% weight/volume of calcium carbonate and 0.6 to 1.2% weight/volume of the sodium salt of an acrylic polymer cross-linked with 1% allyl-sucrose.
Inventors
- 👤 Roger Withington
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0065; A61K31/00; A61K31/70; A61K31/715; A61P; A61P1/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
88 words
A pharmaceutical composition for the suppression of gastric reflux comprising a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, from 0.16 to 2.60 parts by weight of sodium bicarbonate per part by weight of sodium alginate and from 0.10 to 1.04 parts by weight of calcium carbonate per part by weight of sodium alginate.
Claim 2
Dependent Claim
88 words
A pharmaceutical composition for the suppression of gastric reflux comprising a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, from 0.16 to 2.60 parts by weight of sodium bicarbonate per part by weight of sodium alginate and from 0.10 to 1.04 parts by weight of calcium carbonate per part by weight of sodium alginate.
Claim 3
Dependent Claim
55 words
A pharmaceutical composition according to claim 1 wherein the sodium bicarbonate is present in an amount of from 0.33 to 0.88 parts by weight per part by weight of sodium alginate and the calcium carbonate is present in an amount of from 0.2 to 0.5 parts by weight per part by weight of sodium alginate.
Claim 4
Dependent Claim
16 words
A pharmaceutical composition according to claim 1 which is in the form of a dry powder.
Claim 5
Dependent Claim
80 words
A pharmaceutical composition in liquid form for the suppression of gastric reflux comprising an aqueous medium containing 2.5 to 8.0% weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, 1.3 to 6.5% weight/volume of sodium bicarbonate and 0.8 to 2.6% weight/volume of calcium carbonate.
Claim 6
Dependent Claim
80 words
A pharmaceutical composition in liquid form for the suppression of gastric reflux comprising an aqueous medium containing 2.5 to 8.0% weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, 1.3 to 6.5% weight/volume of sodium bicarbonate and 0.8 to 2.6% weight/volume of calcium carbonate.
Claim 7
Dependent Claim
24 words
A pharmaceutical composition according to claim 4 which further includes a suspending agent in an amount effective to maintain the calcium carbonate in suspension.
Claim 8
Dependent Claim
54 words
A pharmaceutical composition according to claim 5 wherein the suspending agent is present in an amount of from 0.3 to 1.7% weight/volume and is selected from the group consisting of the sodium salt of an acrylic polymer cross-linked with less than 3% allyl-sucrose, tragacanth, pectin, pregelatinised potato starch, sodium starch glycolate and mixtures thereof.
Claim 9
Dependent Claim
91 words
A pharmaceutical composition according to claim 4 comprising an aqueous medium containing 4.0 to 6.0% weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, 2.0 to 3.5% weight/volume of sodium bicarbonate, 1.2 to 2.0% weight/volume of calcium carbonate and 0.6 to 1.2% weight/volume of the sodium salt of an acrylic polymer cross-linked with 1% allyl-sucrose.
Claim 10
Dependent Claim
26 words
A pharmaceutical composition according to claim 7 wherein the low viscosity grade sodium alginate has a viscosity in the range of from 3 to 40 centipoise.
Claim 11
Dependent Claim
26 words
A pharmaceutical composition according to claim 7 wherein the low viscosity grade sodium alginate has a viscosity in the range of from 3 to 20 centipoise.
Claim 12
Dependent Claim
12 words
A pharmaceutical composition according to claim 4 which further includes a preservative.
Claim 13
Dependent Claim
32 words
A pharmaceutical composition according to claim 10 wherein the preservative is a mixture of methyl p-hydroxybenzoate and propyl p-hydroxybenzoate which are employed in an amount of 0.4% weight/volume and 0.06% weight/volume, respectively.
Claim 14
Dependent Claim
105 words
A pharmaceutical composition in dry powder form adapted to be mixed with water and drunk by a person in need of suppressing gastric reflux consisting essentially of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, from 0.16 to 2.60 parts by weight of sodium bicarbonate per part by weight of sodium alginate and from 0.10 to 1.04 parts by weight of calcium carbonate per part by weight of sodium alginate.
Claim 15
Dependent Claim
105 words
A pharmaceutical composition in dry powder form adapted to be mixed with water and drunk by a person in need of suppressing gastric reflux consisting essentially of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 60 centipoise, from 0.16 to 2.60 parts by weight of sodium bicarbonate per part by weight of sodium alginate and from 0.10 to 1.04 parts by weight of calcium carbonate per part by weight of sodium alginate.
Claim 16
Dependent Claim
86 words
A pharmaceutical composition in liquid form for the suppression of gastric reflux consisting essentially of the following ingredients in an aqueous medium: from 2.5 to 8.0% weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 40 centipoise, 1.3 to 6.5% weight/volume of sodium bicarbonate and 0.8 to 2.6% weight/volume of calcium carbonate.
Claim 17
Dependent Claim
86 words
A pharmaceutical composition in liquid form for the suppression of gastric reflux consisting essentially of the following ingredients in an aqueous medium: from 2.5 to 8.0% weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No 1 at 20 r.p.m. at 25° C., is within the range of from 3 to 40 centipoise, 1.3 to 6.5% weight/volume of sodium bicarbonate and 0.8 to 2.6% weight/volume of calcium carbonate.
Claim 18
Independent Claim
130 words
A method of treating humans for gastric reflux comprising orally administering to a human an amount of a liquid composition, as defined below, effective to provide relief, said liquid composition comprising an aqueous medium containing 2.5 to 8.0 weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No. 1 at 20 r.p.m. at 25° C. is within the range of from 3 to 60 centipoise, 1.3 to 6.5 weight/volume of sodium bicarbonate and 0.8 to 2.6 weight/volume of calcium carbonate, said ingredients reacting in the presence of gastric acid in the stomach to form a carbonated gel in which alginic acid molecules are cross-linked by calcium ions to strength the gel matrix.
Claim 19
Independent Claim
130 words
A method of treating humans for gastric reflux comprising orally administering to a human an amount of a liquid composition, as defined below, effective to provide relief, said liquid composition comprising an aqueous medium containing 2.5 to 8.0 weight/volume of a low viscosity grade sodium alginate for which the viscosity of a 1% aqueous solution, when determined on a Brookfield viscometer model RVT using spindle No. 1 at 20 r.p.m. at 25° C. is within the range of from 3 to 60 centipoise, 1.3 to 6.5 weight/volume of sodium bicarbonate and 0.8 to 2.6 weight/volume of calcium carbonate, said ingredients reacting in the presence of gastric acid in the stomach to form a carbonated gel in which alginic acid molecules are cross-linked by calcium ions to strength the gel matrix.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |