US4143203A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Particulate support material
Assignee: Amicon Corp
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Filing: 1976-03-19
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Granted: 1979-03-06
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Expires: 1996-03-19
Abstract
Abstract Particles having a mean diameter from 0.1 to 50 micrometers and having a solid core of water-impermeable polyacrylonitrile and a partially hydrolyzed hydrophilic surface layer enclosing the core containing from 0.001 to 0.8 milliequivalents of carboxyl or carboxylate groups per dry gram, the surface layer amounting to 0.01 to 20% by weight of the particles, are useful as a solid phase insoluble support to which biospecific reagents such as antigens or antibodies can be coupled. Variants include supports in which N-hydroxysuccinimide or various spacer arms are coupled to the carboxyl or carboxylate groups.
Inventors
- 👤 Peter N. Rigopulos
- 👤 Charles W. Desaulniers
- 👤 David E. Doucette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:45
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; A; A61; A61K; A61K39/00; A61K39/395; A61K39/44; C; C08; C08F; C08F8/00; C08F8/30; C08F8/44; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
94 words
A particulate support material comprising particles having a mean diameter from 0.1 to 50 micrometers in which the range of particle sizes is within 20% of the mean diameter and the specific gravity of the particles is from 1.1 to 1.2, said particles having a core of water impermeable rigid polyacrylonitrile with a hydrophilic surface layer enclosing said core comprising hydrolyzed polyacrylonitrile having carboxyl or carboxylate groups in an amount from 0.2 to 0.5 milli-equivalent per dry gram of particles, said surface layer amounting to 0.01 to 20 percent by weight of said particles.
Claim 2
Dependent Claim
94 words
A particulate support material comprising particles having a mean diameter from 0.1 to 50 micrometers in which the range of particle sizes is within 20% of the mean diameter and the specific gravity of the particles is from 1.1 to 1.2, said particles having a core of water impermeable rigid polyacrylonitrile with a hydrophilic surface layer enclosing said core comprising hydrolyzed polyacrylonitrile having carboxyl or carboxylate groups in an amount from 0.2 to 0.5 milli-equivalent per dry gram of particles, said surface layer amounting to 0.01 to 20 percent by weight of said particles.
Claim 3
Dependent Claim
85 words
A particulate support material comprising particles having a mean diameter from 0.1 to 50 micrometers and having a core of water impermeable rigid polyacrylonitrile with a hydrophilic surface layer enclosing said core comprising hydrolyzed polyacrylonitrile having carboxyl or carboxylate groups in an amount of 0.001 to 0.8 milli-equivalent per dry gram of particles in which at least 10% of the total carboxyl and carboxylate groups are esterified to N-hydroxysuccinimide ester groups, said surface layer amounting to 0.01 to 20 percent by weight of said particles.
Claim 4
Dependent Claim
85 words
A particulate support material comprising particles having a mean diameter from 0.1 to 50 micrometers and having a core of water impermeable rigid polyacrylonitrile with a hydrophilic surface layer enclosing said core comprising hydrolyzed polyacrylonitrile having carboxyl or carboxylate groups in an amount of 0.001 to 0.8 milli-equivalent per dry gram of particles in which at least 10% of the total carboxyl and carboxylate groups are esterified to N-hydroxysuccinimide ester groups, said surface layer amounting to 0.01 to 20 percent by weight of said particles.
Claim 5
Dependent Claim
54 words
A particulate support material as claimed in claim 2 in which the range of particle sizes is within 20% of the mean diameter and the specific gravity of the particles is from 1.1 to 1.2 and in which at least 30% of the total carboxyl and carboxylate groups are esterified to N-hydroxysuccinimide ester groups.
Claim 6
Dependent Claim
46 words
A particulate support material as claimed in claim 2 in which at least 30% of the total carboxyl and carboxylate groups are esterified to N-hydroxysuccinimide groups and in which the total carboxyl and carboxylate groups amount to 0.2 to 0.5 milliequivalents per dry gram of particles.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-05 | 1982-09-04 | 1983-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-05 | 1986-09-04 | 1987-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-05 | 1990-09-04 | 1991-03-06 | $7700.00 | Window Closed / Lapsed |