US4153695A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted 2,3-dihydro imidazo[1,2-c]pyrimidines
Assignee: Eli Lilly and Co
•
Filing: 1978-03-09
•
Granted: 1979-05-08
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Expires: 1998-03-09
Abstract
Abstract {PG,1 Di-substituted 2,3-dihydroimidazo{8 1,2-c{9 pyrimidines, useful as anti-viral agents.
Inventors
- 👤 William W. Turner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 09:18
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/30; A; A61; A61P; A61P31/00; A61P31/12; A61P37/00; A61P37/02; A61P37/04; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
68 words
A compound of the formula: ##STR3## wherein R is H, C 1 -C 5 alkyl, amino, phenyl or CH 3 --S, R 1 is Cl, and R 2 , R 3 and R 4 individually are H, methyl or phenyl with the proviso that R is H only when one of R 3 and R 4 is methyl, and pharmaceutically-acceptable acid addition salts thereof formed with strong acids.
Claim 2
Dependent Claim
68 words
A compound of the formula: ##STR3## wherein R is H, C 1 -C 5 alkyl, amino, phenyl or CH 3 --S, R 1 is Cl, and R 2 , R 3 and R 4 individually are H, methyl or phenyl with the proviso that R is H only when one of R 3 and R 4 is methyl, and pharmaceutically-acceptable acid addition salts thereof formed with strong acids.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, said compound being 5-methyl-7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidine.
Claim 4
Dependent Claim
9 words
The hydrochloride salt of the base of claim 2.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, said compound being 5-methylthio-7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidine.
Claim 6
Dependent Claim
9 words
The hydrochloride salt of the base of claim 4.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, said compound being 5-thiomethyl-7-chloro-8-phenyl-2,3-dihydroimidazo[1,2-c]pyrimidine.
Claim 8
Dependent Claim
9 words
The hydrochloride salt of the base of claim 6.
Claim 9
Dependent Claim
10 words
A compound according to claim 1, said compound being 3-phenyl-5-methyl-7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidine.
Claim 10
Dependent Claim
9 words
The hydrochloride salt of the base of claim 8.
Claim 11
Dependent Claim
10 words
A compound according to claim 1, said compound being 5-ethyl-7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidine.
Claim 12
Dependent Claim
9 words
The hydrochloride salt of the base of claim 10.
Claim 13
Dependent Claim
33 words
The process of treating Herpes simplex infections on skin or mucosal membranes which comprises applying to said infected surface an anti-Herpes concentration of a compound according to claim 1 in a non-irritating vehicle.
Claim 14
Dependent Claim
34 words
A pharmaceutical composition in unit dosage form for the topical treatment of Herpes simplex infections consisting of a non-irritating pharmaceutical carrier and as its therapeutic agent, 0.5-2.52 of a compound according to claim 1.
Claim 15
Dependent Claim
8 words
N-(β-Chloroethyl)-7-amino-8-nitro-2,3-dihydroimidazo[1,2-c]pyrimidine and its pharmaceutically acceptable acid addition salts.
Claim 16
Dependent Claim
8 words
N-(β-Chloroethyl)-7-amino-8-nitro-2,3-dihydroimidazo[1,2-c]pyrimidine and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
US3769288A
Cited
DE2511316A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-07 | 1982-11-06 | 1983-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-07 | 1986-11-06 | 1987-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-07 | 1990-11-06 | 1991-05-08 | $7700.00 | Window Closed / Lapsed |