US4166902A
Expired / Lapsed
US
⏱️ 0.0 years remaining
High polymers containing nicotinic acid, process for their preparation and their use
Assignee: Individual
•
Filing: 1978-01-09
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Granted: 1979-09-04
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Expires: 1998-01-09
Abstract
Abstract New polymers consisting of a macromolecular structure of soluble starch to which 15-30% of nicotinic acid radicals are bound through covalent ester bonds. These polymers are gradually hydrolized in biological environment by setting free nicotinic acid and non toxic polysaccharide residues. These polymers have a therapeutic activity similar to that of nicotinic acid, but by far more long lasting and devoid of collateral effects.
Inventors
- 👤 Paolo Ferruti
- 👤 Rodolfo Paoletti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:03
CPC Classifications
C; C08; C08B; C08B31/00; C08B31/02; C08F; C08F8/00; C08F8/30
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
44 words
Polymers characterized in that they consist of a soluble starch macromolecular structure to which 15-30% by weight of nicotinic acid radicals are bound through covalent ester bonds, which polymers are gradually hydrolyzed in biological evironment by setting free nicotinic acid and non-toxic polysaccharide residues.
Claim 2
Dependent Claim
44 words
Polymers characterized in that they consist of a soluble starch macromolecular structure to which 15-30% by weight of nicotinic acid radicals are bound through covalent ester bonds, which polymers are gradually hydrolyzed in biological evironment by setting free nicotinic acid and non-toxic polysaccharide residues.
Claim 3
Dependent Claim
30 words
A Process for preparing polymers as defined in claim 1, wherein soluble starch is reacted with 1-nicotinoylimidazole in the presence of an anhydrous organic solvent under an inert gas atmosphere.
Claim 4
Dependent Claim
25 words
A process according to claim 2, wherein the organic solvent is anhydrous dimethylsulphoxide and the reaction is performed at a temperature of about 60° C.
Claim 5
Dependent Claim
26 words
A process according to claim 3, wherein the product is precipitated by pouring the dimethylsulphoxide solution into a large volume of a 1:1 ether: acetone mixture.
Claim 6
Dependent Claim
16 words
A therapeutic composition containing a therapeutically effective amount of a polymer as defined in claim 1.
References Cited (Backward Citations)
US4067876A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-03 | 1983-03-05 | 1983-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-03 | 1987-03-05 | 1987-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-03 | 1991-03-05 | 1991-09-04 | $7700.00 | Window Closed / Lapsed |