US4189401A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of storing a biological reference control standard and biological reference control standard obtained thereby
Assignee: Beckman Coulter Inc
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Filing: 1978-07-17
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Granted: 1980-02-19
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Expires: 1998-07-17
Abstract
Abstract An improved method of storing and shipping a blood serum reference composition comprising in its non-biological component from about 40 to about 85 weight percent water, from about 15 to about 60 weight percent of at least one alkylene polyol having from 2-5 carbon atoms, the remainder being chiefly at least one natural biological material selected from a group consisting of blood serum, enzyme, metabolites, electrolytes, and hormones. The improvement comprises storing and/or shipping the composition at a temperature below the freezing point thereof.
Inventors
- 👤 Allan L. Louderback
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 08:58
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/05; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/104165; Y10T436/104998; Y10T436/105831; Y10T436/106664; Y10T436/108331; Y10T436/109163
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
104 words
An improved method of storing a blood serum reference composition for subsequent use in analysis of biologically similar unknowns, said composition comprising in its non-biological component from about 40 to about 85 weight percent water, from about 15 to about 60 weight percent of at least one alkylene polyol having from 2 to 5 carbon atoms, the remainder being chiefly at least one labile natural biological material selected from a group consisting of blood serum, enzyme, metabolites, electrolytes, and hormones, wherein the improvement comprises lowering the temperature of said composition to below the freezing point thereof and storing said composition in a frozen state.
Claim 2
Dependent Claim
104 words
An improved method of storing a blood serum reference composition for subsequent use in analysis of biologically similar unknowns, said composition comprising in its non-biological component from about 40 to about 85 weight percent water, from about 15 to about 60 weight percent of at least one alkylene polyol having from 2 to 5 carbon atoms, the remainder being chiefly at least one labile natural biological material selected from a group consisting of blood serum, enzyme, metabolites, electrolytes, and hormones, wherein the improvement comprises lowering the temperature of said composition to below the freezing point thereof and storing said composition in a frozen state.
Claim 3
Dependent Claim
54 words
The method of claim 1 wherein said non-biological component comprises from about 60 to about 80 weight percent water and from about 20 to about 40 weight percent of said alkylene polyol and wherein said composition is stored at a temperature below the freezing point thereof and above the freezing point of carbon dioxide.
Claim 4
Dependent Claim
21 words
The method of claim 2 wherein said composition is stored at a temperature of from about -25° to about -75° C.
Claim 5
Dependent Claim
21 words
The method of claim 3 wherein said composition is stored at a temperature of from about -40° to about -50° C.
Claim 6
Dependent Claim
44 words
The method of claim 1 wherein said non-biological component comprises from about 60 to about 80 weight percent water and from about 20 to about 40 weight percent of said alkylene polyol and wherein said composition is stored at a temperature below -25° C.
Claim 7
Dependent Claim
77 words
A frozen blood serum reference composition for use in analysis of biologically similar unknowns upon thawing, said composition comprising in its non-biological component from about 40 to about 85 weight percent water, from about 15 to about 60 weight percent of at least one alkylene polyol having from 2 to 5 carbon atoms, the remainder being chiefly at least one labile natural biological material selected from a group consisting of blood serum, enzymes, metabolites, electrolytes, and hormones.
Claim 8
Dependent Claim
77 words
A frozen blood serum reference composition for use in analysis of biologically similar unknowns upon thawing, said composition comprising in its non-biological component from about 40 to about 85 weight percent water, from about 15 to about 60 weight percent of at least one alkylene polyol having from 2 to 5 carbon atoms, the remainder being chiefly at least one labile natural biological material selected from a group consisting of blood serum, enzymes, metabolites, electrolytes, and hormones.
Claim 9
Dependent Claim
53 words
The composition of claim 6 wherein said non-biological component comprises from about 60 to about 80 weight percent water and from about 20 to about 40 weight percent of said alkylene polyol and wherein said composition is frozen at a temperature below its freezing point and above the freezing point of carbon dioxide.
Claim 10
Dependent Claim
21 words
The composition of claim 7 wherein said composition is frozen at a temperature of from about -25° to about -75° C.
Claim 11
Dependent Claim
21 words
The composition of claim 8 wherein said composition is frozen at a temperature of from about -40° to about -50° C.
Claim 12
Dependent Claim
44 words
The composition of claim 6 wherein said nonbiological component comprises from about 60 to about 80 weight percent water and from about 20 to about 40 weight percent of said alkylene polyol and wherein said composition is frozen at a temperature below -25° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-18 | 1983-08-20 | 1984-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-18 | 1987-08-20 | 1988-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-18 | 1991-08-20 | 1992-02-19 | $7700.00 | Window Closed / Lapsed |