US4189501A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition and method for the treatment of acne
Assignee: AHC Pharmacal Inc
•
Filing: 1977-10-07
•
Granted: 1980-02-19
•
Expires: 1997-10-07
Abstract
Abstract Compositions containing organic peroxides are effective for the treatment of acne. Decomposition of the organic peroxide during storage is prevented by the incorporation of glycerol which is sufficiently effective so that decomposition is prevented even in those peroxides which are so unstable as to be explosive.
Inventors
- 👤 James E. Fulton, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:09
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/38
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
38 words
A composition, comprising a dispersion of about 10 weight % of benzoyl peroxide in an aqueous solution containing about 20 volume % glycerol to inhibit decomposition of said peroxide, said composition being effective in the treatment of acne.
Claim 2
Dependent Claim
38 words
A composition, comprising a dispersion of about 10 weight % of benzoyl peroxide in an aqueous solution containing about 20 volume % glycerol to inhibit decomposition of said peroxide, said composition being effective in the treatment of acne.
Claim 3
Dependent Claim
22 words
The composition as claimed in claim 1, further comprising sufficient gelling agent to increase the viscosity thereof to that of a grease.
Claim 4
Dependent Claim
21 words
The composition as claimed in claim 1, wherein said composition further contains 5 to 100 grams of gelling agent per liter.
Claim 5
Dependent Claim
28 words
The composition as claimed in claim 3, wherein said gelling agent is selected from the group consisting of carboxymethyl cellulose, magnesium aluminum silicate, finely-divided silica and carboxyvinyl copolymer.
Claim 6
Dependent Claim
25 words
The composition as claimed in claim 1, in combination with sufficient alkali to bring the pH of said dispersion to between about 3.5 and 5.0.
Claim 7
Dependent Claim
28 words
The composition as claimed in claim 1, wherein said gelling agent is carboxyvinyl copolymer in a concentration range of 5 to 20 grams per liter of said composition.
Claim 8
Dependent Claim
21 words
The composition as claimed in claim 1, further comprising from 10 to 300 grams of finely-divided sulphur per liter of same.
Claim 9
Dependent Claim
16 words
The composition as claimed in claim 1, further comprising an effective amount of a surfactant compound.
Claim 10
Dependent Claim
15 words
The composition as claimed in claim 1, further comprising a coloring amount of a pigment.
Claim 11
Independent Claim
72 words
A method of treatment of acne, comprising the step of applying topically to an affected area a composition comprising an aqueous dispersion of an organic peroxide effective in the treatment of acne, each liter of said composition comprising about 100 grams of benzoyl peroxide, about 200 ml of glycerol, from 0-200 ml of propylene glycol and water, said step being repeated until a desired decrease in severity of said acne is achieved.
Claim 12
Independent Claim
72 words
A method of treatment of acne, comprising the step of applying topically to an affected area a composition comprising an aqueous dispersion of an organic peroxide effective in the treatment of acne, each liter of said composition comprising about 100 grams of benzoyl peroxide, about 200 ml of glycerol, from 0-200 ml of propylene glycol and water, said step being repeated until a desired decrease in severity of said acne is achieved.
Claim 13
Dependent Claim
22 words
The method as defined in claim 10, wherein each liter of said composition further comprises 5 to 100 grams of gelling agent.
Claim 14
Dependent Claim
30 words
The method as defined in claim 11, wherein said gelling agent is a member selected from the group consisting of carboxymethyl cellulose, magnesium aluminum silicate, finely-divided silica and carboxyvinyl copolymer.
Claim 15
Dependent Claim
27 words
The method as defined in claim 11, wherein said gelling agent is carboxyvinyl copolymer in an amount of 5 to 20 grams per liter of said composition.
Claim 16
Dependent Claim
31 words
The method as defined in claim 10, wherein each liter of said composition contains alkali in an amount such that the pH of said composition lies between about 3.5 and 5.0.
Claim 17
Dependent Claim
20 words
The method as defined in claim 10, wherein each liter of said dispersion further includes 10-300 grams of finely-divided sulphur.
Claim 18
Dependent Claim
34 words
The method as defined in claim 15, further comprising the step of applying retinoic acid to said affected area at a time of day when said affected area is essentially free of said dispersion.
Claim 19
Dependent Claim
53 words
The method as defined in claim 10, wherein said dispersion is applied daily and allowed to remain on said affected area for a period up to about 6 hours, said period being commensurate with the resistance of the skin to irritation by said dispersion, and comprising the step of removal of said dispersion.
Claim 20
Dependent Claim
34 words
A surgical scrub soap, comprising about 10 weight % of benzoyl peroxide, and about 20 volume % of glycerol to stabilize said peroxide, said soap being free of ingredients reactive with said benzoyl peroxide.
Claim 21
Dependent Claim
34 words
A surgical scrub soap, comprising about 10 weight % of benzoyl peroxide, and about 20 volume % of glycerol to stabilize said peroxide, said soap being free of ingredients reactive with said benzoyl peroxide.
References Cited (Backward Citations)
US3535422A
Cited
US4056611A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-18 | 1983-08-20 | 1984-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-18 | 1987-08-20 | 1988-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-18 | 1991-08-20 | 1992-02-19 | $7700.00 | Window Closed / Lapsed |