US4195087A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of naphthyridine
Assignee: Abic Ltd
•
Filing: 1977-12-06
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Granted: 1980-03-25
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Expires: 1997-12-06
Abstract
Abstract The present invention deals with derivatives of naphthyridine, process for their preparation and their utility, inter alia, as anti-bacterides and as feed-additives.
Inventors
- 👤 Chaim Simonovitch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:57
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A23; A23K; A23K20/00; A23K20/10; A23K20/116; A23K20/137; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
175 words
3-Carboxy-4-oxo-1,40dihydro-1, 8-napthyridines of the formula ##STR5## wherein R 1 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms and cycloalkyl, Z stands for oxygen, n is 0 or 1, and R 2 is selected from the group consisting of the group OH; the group C 6 H 5 ; the group --NHR 1 wherein R 1 has the same definition as above; the group ##STR6## wherein R 3 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms, cycloalkyl, NH 2 , NHNH 2 , OR 1 wherein R 1 has the same definition as above, phenyl, phenyl--OH and phenyl--NO 2 and wherein R 4 stands for O or NH; the group C 6 H 5 --R 1 wherein R 1 has the same definition as above; the group C 6 H 5 --Hal wherein Hal is a halogen; and a heterocyclic group selected from the group consisting of ##STR7## wherein R 1 has the same definition as above; and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
175 words
3-Carboxy-4-oxo-1,40dihydro-1, 8-napthyridines of the formula ##STR5## wherein R 1 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms and cycloalkyl, Z stands for oxygen, n is 0 or 1, and R 2 is selected from the group consisting of the group OH; the group C 6 H 5 ; the group --NHR 1 wherein R 1 has the same definition as above; the group ##STR6## wherein R 3 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms, cycloalkyl, NH 2 , NHNH 2 , OR 1 wherein R 1 has the same definition as above, phenyl, phenyl--OH and phenyl--NO 2 and wherein R 4 stands for O or NH; the group C 6 H 5 --R 1 wherein R 1 has the same definition as above; the group C 6 H 5 --Hal wherein Hal is a halogen; and a heterocyclic group selected from the group consisting of ##STR7## wherein R 1 has the same definition as above; and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
10 words
Compound according to claim 1 being 1-[-7(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]-4-methyl piperazine HCl.
Claim 4
Dependent Claim
8 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]pyrolidine.
Claim 5
Dependent Claim
9 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]morpholine.
Claim 6
Dependent Claim
8 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidine amino)]piperidine.
Claim 7
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7 carboxaldehyde acethydrazone.
Claim 8
Dependent Claim
8 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(4'hydroxyphenyl)hydrazone.
Claim 9
Dependent Claim
10 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(4 nitro-phenyl) hydrazone.
Claim 10
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde(2-nitro-phenyl) hydrazone.
Claim 11
Dependent Claim
11 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4 dihydro-1,8-naphthyridine-7-carboxaldehyde ethyl carbazone.
Claim 12
Dependent Claim
10 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4 dihydro-1,8-naphthyridine-7-carboxaldehyde-thio carbohydrazone.
Claim 13
Dependent Claim
10 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]2 mercapto-1,3,5-triazole.
Claim 14
Dependent Claim
10 words
Compound according to claim 1 being N-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene)]-N 1 -[2(5-nitrofurylidene)]-azine.
Claim 15
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 8 naphthyridine-7-carboxaldoxime.
Claim 16
Dependent Claim
8 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxaldehyde semicarbazone.
Claim 17
Dependent Claim
9 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]guanidine.
Claim 18
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyrilidene-7-carboxaldehyde carbohydrazone.
Claim 19
Dependent Claim
8 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]oxazolidone.
Claim 20
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(β-hydroxyethyl) nitrone.
Claim 21
Dependent Claim
7 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyride-7-carboxaldehyde(N-ethyl)hydrazine.
Claim 22
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-(phenyl-amino)carboxaldehyde; m.p. 290°.
Claim 23
Dependent Claim
9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydrol-1,8 naphthyridine-7-[(4-ethoxy-phenylamino)]carboxaldehyde.
Claim 24
Dependent Claim
7 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxaldoxime.
Claim 25
Dependent Claim
18 words
A pharmaceutical composition comprising an antibacterial effect amount of the compound claim 1 and a pharmaceutically acceptable carrier.
Claim 26
Dependent Claim
13 words
A feed premix including an effective amount of the compound of claim 1.
Claim 27
Dependent Claim
17 words
An animal feed comprising an animal foodstuff and an effective amount of the compound of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-25 | 1983-09-24 | 1984-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-25 | 1987-09-24 | 1988-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-25 | 1991-09-24 | 1992-03-25 | $7700.00 | Window Closed / Lapsed |