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US4195087A Expired / Lapsed US ⏱️ 0.0 years remaining

Derivatives of naphthyridine

Assignee: Abic Ltd
•
Filing: 1977-12-06
•
Granted: 1980-03-25
•
Expires: 1997-12-06
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Abstract

Abstract The present invention deals with derivatives of naphthyridine, process for their preparation and their utility, inter alia, as anti-bacterides and as feed-additives.

Inventors

  • 👤 Chaim Simonovitch

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 09:57
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A23; A23K; A23K20/00; A23K20/10; A23K20/116; A23K20/137; A61; A61P; A61P31/00; A61P31/04

Claims Analysis

Total Claims: 27
Claim 1
Independent Claim 175 words
3-Carboxy-4-oxo-1,40dihydro-1, 8-napthyridines of the formula ##STR5## wherein R 1 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms and cycloalkyl, Z stands for oxygen, n is 0 or 1, and R 2 is selected from the group consisting of the group OH; the group C 6 H 5 ; the group --NHR 1 wherein R 1 has the same definition as above; the group ##STR6## wherein R 3 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms, cycloalkyl, NH 2 , NHNH 2 , OR 1 wherein R 1 has the same definition as above, phenyl, phenyl--OH and phenyl--NO 2 and wherein R 4 stands for O or NH; the group C 6 H 5 --R 1 wherein R 1 has the same definition as above; the group C 6 H 5 --Hal wherein Hal is a halogen; and a heterocyclic group selected from the group consisting of ##STR7## wherein R 1 has the same definition as above; and physiologically acceptable salts thereof.
Claim 2
Dependent Claim 175 words
3-Carboxy-4-oxo-1,40dihydro-1, 8-napthyridines of the formula ##STR5## wherein R 1 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms and cycloalkyl, Z stands for oxygen, n is 0 or 1, and R 2 is selected from the group consisting of the group OH; the group C 6 H 5 ; the group --NHR 1 wherein R 1 has the same definition as above; the group ##STR6## wherein R 3 is selected from the group consisting of straight and branched alkyl of 1-7 carbon atoms, cycloalkyl, NH 2 , NHNH 2 , OR 1 wherein R 1 has the same definition as above, phenyl, phenyl--OH and phenyl--NO 2 and wherein R 4 stands for O or NH; the group C 6 H 5 --R 1 wherein R 1 has the same definition as above; the group C 6 H 5 --Hal wherein Hal is a halogen; and a heterocyclic group selected from the group consisting of ##STR7## wherein R 1 has the same definition as above; and physiologically acceptable salts thereof.
Claim 3
Dependent Claim 10 words
Compound according to claim 1 being 1-[-7(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]-4-methyl piperazine HCl.
Claim 4
Dependent Claim 8 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]pyrolidine.
Claim 5
Dependent Claim 9 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]morpholine.
Claim 6
Dependent Claim 8 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidine amino)]piperidine.
Claim 7
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7 carboxaldehyde acethydrazone.
Claim 8
Dependent Claim 8 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(4'hydroxyphenyl)hydrazone.
Claim 9
Dependent Claim 10 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(4 nitro-phenyl) hydrazone.
Claim 10
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde(2-nitro-phenyl) hydrazone.
Claim 11
Dependent Claim 11 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4 dihydro-1,8-naphthyridine-7-carboxaldehyde ethyl carbazone.
Claim 12
Dependent Claim 10 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4 dihydro-1,8-naphthyridine-7-carboxaldehyde-thio carbohydrazone.
Claim 13
Dependent Claim 10 words
Compound according to claim 1 being 1-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]2 mercapto-1,3,5-triazole.
Claim 14
Dependent Claim 10 words
Compound according to claim 1 being N-[7(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene)]-N 1 -[2(5-nitrofurylidene)]-azine.
Claim 15
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 8 naphthyridine-7-carboxaldoxime.
Claim 16
Dependent Claim 8 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxaldehyde semicarbazone.
Claim 17
Dependent Claim 9 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4 dihydro-1,8-naphthyrilidene amino)]guanidine.
Claim 18
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyrilidene-7-carboxaldehyde carbohydrazone.
Claim 19
Dependent Claim 8 words
Compound according to claim 1 being 1-[7-(1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyrilidene amino)]oxazolidone.
Claim 20
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydro-1,8-naphthyridine-7-carboxaldehyde-(β-hydroxyethyl) nitrone.
Claim 21
Dependent Claim 7 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyride-7-carboxaldehyde(N-ethyl)hydrazine.
Claim 22
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-(phenyl-amino)carboxaldehyde; m.p. 290°.
Claim 23
Dependent Claim 9 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1, 4-dihydrol-1,8 naphthyridine-7-[(4-ethoxy-phenylamino)]carboxaldehyde.
Claim 24
Dependent Claim 7 words
Compound according to claim 1 being 1-ethyl-3-carboxy-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxaldoxime.
Claim 25
Dependent Claim 18 words
A pharmaceutical composition comprising an antibacterial effect amount of the compound claim 1 and a pharmaceutically acceptable carrier.
Claim 26
Dependent Claim 13 words
A feed premix including an effective amount of the compound of claim 1.
Claim 27
Dependent Claim 17 words
An animal feed comprising an animal foodstuff and an effective amount of the compound of claim 1.

References Cited (Backward Citations)

US3149104A Cited
US3516994A Cited
US3846413A Cited
US3829492A Cited
US3997528A Cited
US4011214A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-03-25 1983-09-24 1984-03-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-03-25 1987-09-24 1988-03-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-03-25 1991-09-24 1992-03-25 $7700.00 Window Closed / Lapsed

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