US4196143A
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Substituted phenoxyalkyl quaternary ammonium compounds
Assignee: Dow Chemical Co
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Filing: 1977-10-11
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Granted: 1980-04-01
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Expires: 1997-10-11
Abstract
Abstract Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-β-dimethylamino-p-phenetidine with a substituted organic compound such as allyl bromide. The quaternary ammonium compounds are useful in alleviating or inhibiting cardiac arrhythmias when the quaternary ammonium compounds, or compositions comprising the same are administered to animals.
Inventors
- 👤 Stanley J. Strycker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:12
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/06; C07D213/16; C07D213/20; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D453/00; C07D453/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
98 words
A quaternary ammonium compound corresponding to the formula: ##STR8## wherein Y represents amino, loweralkylamino or diloweralkylamino; R 1 and R 2 represent lower alkyl; R 3 independently represents substituted lower alkyl, substituted lower alkenyl or substituted lower alkynyl substituted with a substituent selected from phenyl, halophenyl, dihalophenyl or trihalophenyl; X 1 and X 2 both represent halogen; A - represents a stoichiometric equivalent quantity of a pharmaceutically-acceptable anion; n represents one of the integers 2, 3 or 4; HX represents a stoichiometric equivalent quantity of a pharmaceutically-acceptable acid; and m represents one of the integers zero and one.
Claim 2
Dependent Claim
98 words
A quaternary ammonium compound corresponding to the formula: ##STR8## wherein Y represents amino, loweralkylamino or diloweralkylamino; R 1 and R 2 represent lower alkyl; R 3 independently represents substituted lower alkyl, substituted lower alkenyl or substituted lower alkynyl substituted with a substituent selected from phenyl, halophenyl, dihalophenyl or trihalophenyl; X 1 and X 2 both represent halogen; A - represents a stoichiometric equivalent quantity of a pharmaceutically-acceptable anion; n represents one of the integers 2, 3 or 4; HX represents a stoichiometric equivalent quantity of a pharmaceutically-acceptable acid; and m represents one of the integers zero and one.
Claim 3
Dependent Claim
22 words
A compound of claim 1 wherein Y is amino and wherein X 1 and X 2 are both chlorine or both bromine.
Claim 4
Dependent Claim
50 words
A compound of claim 1 wherein R 1 and R 2 together contain from 2 to 6 carbon atoms, inclusive, and R 3 contains from 3 to 7 carbon atoms, inclusive, and wherein R 1 , R 2 and R 3 together contain from 5 to 9 carbon atoms, inclusive.
Claim 5
Dependent Claim
12 words
A compound of claim 1 wherein the compound is [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (2-chlorobenzyl)-ammonium chloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-01 | 1983-10-01 | 1984-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-01 | 1987-10-01 | 1988-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-01 | 1991-10-01 | 1992-04-01 | $7700.00 | Window Closed / Lapsed |