US4223011A
Expired / Lapsed
US
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Therapeutic compositions containing polymers having polyunsaturated acid radicals
Assignee: Individual
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Filing: 1979-03-09
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Granted: 1980-09-16
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Expires: 1999-03-09
Abstract
Abstract A polymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienic acid, 5,8,11,14-eicosatetraenoic acid, and 5,8,11,14,17-eicosapentenoic acid, bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic or oxyaminoalkylenic chains.
Inventors
- 👤 Paolo Ferruti
- 👤 Rodolfo Paoletti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:16
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/14; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; C08F8/10; C08F8/30; C08G; C08G81/00; C08G81/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
111 words
A therapeutic composition containing a therapeutically effective dose of a non-toxic polymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; and 5,8,11,14,17-eicosapentenoic acid, bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chains, said polymer containing units of the formula ##STR1## wherein R is H or CH 3 , A represents an alkylene radical terminated at its ends with an --NH-- group or an --O-- group, and B represents a radical of such polyunsaturated acid sans a carboxylic group and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
111 words
A therapeutic composition containing a therapeutically effective dose of a non-toxic polymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; and 5,8,11,14,17-eicosapentenoic acid, bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chains, said polymer containing units of the formula ##STR1## wherein R is H or CH 3 , A represents an alkylene radical terminated at its ends with an --NH-- group or an --O-- group, and B represents a radical of such polyunsaturated acid sans a carboxylic group and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
28 words
The therapeutic composition of claim 1 wherein said alkylene radical is derived from the compounds selected from the group consisting of N,N-dihydroxy ethyl-1,3-propanediamine, ethanolamine, ethylene diamine, and ethyleneglycol.
Claim 4
Dependent Claim
141 words
A therapeutic composition containing a therapeutically effective dose of a non-toxic copolymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; and 5,8,11,14,17-eicosapentenoic acid, bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chains, said polymer containing units of the formula ##STR2## wherein R is H or CH 3 , A represents an alkylene radical terminated at its end with an --NH-- group or an --O-- groups, B represents a radical of such polyunsaturated acid sans a carboxyl group, and D represents a divalent radical supplied by a comonomer selected from the group consisting of 1-acryloyl-4-methyl piperazine, N-acryloyl morpholine, N-vinyl pyrrolidone, divinylbenzene, methylene bis-acrylamide, N,N'-bisacryloyl piperazine, and N,N-bisacryloyl N,N'-dimethylethylene diamine and a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
141 words
A therapeutic composition containing a therapeutically effective dose of a non-toxic copolymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; and 5,8,11,14,17-eicosapentenoic acid, bound to a macromolecular backbone of polyacrylic or polymethacrylic units through oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chains, said polymer containing units of the formula ##STR2## wherein R is H or CH 3 , A represents an alkylene radical terminated at its end with an --NH-- group or an --O-- groups, B represents a radical of such polyunsaturated acid sans a carboxyl group, and D represents a divalent radical supplied by a comonomer selected from the group consisting of 1-acryloyl-4-methyl piperazine, N-acryloyl morpholine, N-vinyl pyrrolidone, divinylbenzene, methylene bis-acrylamide, N,N'-bisacryloyl piperazine, and N,N-bisacryloyl N,N'-dimethylethylene diamine and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
28 words
The therapeutic composition of claim 3 wherein said alkylene radical is derived from the compounds selected from the group consisting of N,N-dihydroxy ethyl-1,3-propanediamine, ethanolamine, ethylene diamine, and ethyleneglycol.
References Cited (Backward Citations)
US3897513A
Cited
US4145320A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-16 | 1984-03-17 | 1984-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-16 | 1988-03-17 | 1988-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-16 | 1992-03-17 | 1992-09-16 | $7700.00 | Window Closed / Lapsed |