US4223017A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biologically active amides
Assignee: SmithKline Beecham Corp
•
Filing: 1979-02-08
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Granted: 1980-09-16
•
Expires: 1999-02-08
Abstract
Abstract A polypeptide, designated Pancreatic Hormone III, together with pharmaceutically acceptable salts or metal complexes thereof; pharmaceutical formulations of the said polypeptide or its salts or complexes and the preparation of such formulations; and the use of the said polypeptide, salts and complexes in human and veterinary medicine in effecting a reduction in weight or in appetite or in the treatment of obesity, hyperglycaemia or hyperinsulinaemia.
Inventors
- 👤 Norman R. Lazarus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:31
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
43 words
A method of treating a mammal for hyperglycaemia comprising the parenteral administration to the mammal suffering from hyperglycaemia of a nontoxic hyperglycaemia treatment effective amount of a polypeptide designated Pancreatic Hormone III or a pharmaceutically acceptable salt or metal complex of said polypeptide.
Claim 2
Independent Claim
43 words
A method of treating a mammal for hyperglycaemia comprising the parenteral administration to the mammal suffering from hyperglycaemia of a nontoxic hyperglycaemia treatment effective amount of a polypeptide designated Pancreatic Hormone III or a pharmaceutically acceptable salt or metal complex of said polypeptide.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein said mammal is man.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein said polypeptide is derived from the pancreas of pig, ox or a bird.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein said polypeptide is derived from the pancreas of an ox.
Claim 6
Dependent Claim
24 words
The method of claim 1 wherein said polypeptide has the structure: ______________________________________
Ala.Pro.Leu.Glu.Pro.Gln.Tyr.Pro.Gly.Asp.Asp.Ala.
1 6
Thr.Pro.Glu.Gln.Met.Ala.Gln.Tyr.Ala.Ala.Glu.Leu.
13 18 24
Arg.Arg.Tyr.Ile.Asn.Met.Leu.Thr.Arg.Pro.Arg.TyrNh.sub.2
25 30 36
______________________________________
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the polypeptide is administered as the free polypeptide.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the polypeptide is administered as an aqueous solution.
Claim 9
Dependent Claim
29 words
The method of claim 1 wherein the polypeptide is administered in an amount of from 0.01 to 100.0 microgram per kilogram body weight of the animal to be treated.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein said polypeptide is administered subcutaneously.
References Cited (Backward Citations)
CH351565A
Cited
FR1951M
Cited
US3676551A
Cited
FR1407807A
Cited
FR2123524A1
Cited
US3868356A
Cited
US3868357A
Cited
FR2204409A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-16 | 1984-03-17 | 1984-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-16 | 1988-03-17 | 1988-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-16 | 1992-03-17 | 1992-09-16 | $7700.00 | Window Closed / Lapsed |