US4228150A
Expired / Lapsed
US
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Method of inhibiting dextransucrase and oral compositions for use therein
Assignee: Iowa State University Research Foundation Inc
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Filing: 1979-04-23
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Granted: 1980-10-14
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Expires: 1999-04-23
Abstract
Abstract Dextransucrase synthesis of dextran from sucrose is inhibited by novel fluorosucroses which are substituted with fluorine for at least the C6 hydroxyl, and which may also be substituted with fluorine for other hydroxyls. Oral compositions containing such fluorosucrose can be used to control dextran formation in the mouth. Dextran comprises the principal component of dental plaque.
Inventors
- 👤 John F. Robyt
- 👤 John N. Zikopoulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:53
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/69; A23; A23G; A23G3/00; A23G3/34; A23G3/346; A61K8/60; A61Q; A61Q11/00; C; C07; C07H; C07H5/00; C07H5/02; A23G2200/00; A23G2200/06; A61K2800/00; A61K2800/74; A61K2800/78; A61K2800/782
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
45 words
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of at least one fluorosucrose which has been substituted at least at the 6-position with a fluorine atom for the hydroxyl group.
Claim 2
Independent Claim
45 words
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of at least one fluorosucrose which has been substituted at least at the 6-position with a fluorine atom for the hydroxyl group.
Claim 3
Dependent Claim
23 words
The method of claim 1 in which said fluorosucrose is selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 4
Dependent Claim
11 words
The method of claim 1 in which said fluorosucrose is 6-fluorosucrose.
Claim 5
Dependent Claim
11 words
The method of claim 1 in which said fluorosucrose is 6,1'-difluorosucrose.
Claim 6
Dependent Claim
11 words
The method of claim 1 in which said fluorosucrose is 6,6'-difluorosucrose.
Claim 7
Dependent Claim
11 words
The method of claim 1 in which said fluorosucrose is 6,1',6'-trifluorosucrose.
Claim 8
Dependent Claim
18 words
The method of claim 1 in which said fluorosucrose comprises a mixture of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose.
Claim 9
Dependent Claim
41 words
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of at least one fluorosucrose effective for inhibiting the dextransucrase synthesis of dextran, said fluorosucrose having fluorine substituted for at least the C 6 hydroxyl.
Claim 10
Dependent Claim
41 words
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of at least one fluorosucrose effective for inhibiting the dextransucrase synthesis of dextran, said fluorosucrose having fluorine substituted for at least the C 6 hydroxyl.
Claim 11
Dependent Claim
21 words
The oral composition of claim 8 in which said fluorosucrose comprises a mixture of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 12
Dependent Claim
12 words
The oral composition of claim 8 in which said fluorosucrose is 6-fluorosucrose.
Claim 13
Dependent Claim
12 words
The oral composition of claim 8 in which said fluorosucrose is 6,1'-difluorosucrose.
Claim 14
Dependent Claim
12 words
The oral composition of claim 8 in which said fluorosucrose is 6,6'-difluorosucrose.
Claim 15
Dependent Claim
12 words
The oral composition of claim 8 in which said fluorosucrose is 6,1',6'-trifluorosucrose.
Claim 16
Dependent Claim
13 words
The oral composition of claim 8 in which said carrier is a toothpaste.
Claim 17
Dependent Claim
13 words
The oral composition of claim 8 in which said carrier is a toothpowder.
Claim 18
Dependent Claim
14 words
The oral composition of claim 8 in which said carrier is a chewing gum.
Claim 19
Dependent Claim
15 words
The oral composition of claim 8 in which said carrier is a water soluble tablet.
Claim 20
Dependent Claim
13 words
The oral composition of claim 8 in which said carrier is a mouthwash.
Claim 21
Dependent Claim
28 words
A toothpaste containing from 1 to 5 weight percent of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 22
Dependent Claim
28 words
A toothpaste containing from 1 to 5 weight percent of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 23
Dependent Claim
29 words
A mouthwash containing from 20 to 30 grams per liter of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 24
Dependent Claim
29 words
A mouthwash containing from 20 to 30 grams per liter of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 25
Dependent Claim
37 words
Water soluble tablets suitable for use in the mouth, containing from 1 to 5 weight percent per table of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 26
Dependent Claim
37 words
Water soluble tablets suitable for use in the mouth, containing from 1 to 5 weight percent per table of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 27
Dependent Claim
31 words
Chewing gum in stick form containing from 1 to 5 weight percent of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 28
Dependent Claim
31 words
Chewing gum in stick form containing from 1 to 5 weight percent of C 6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Claim 29
Dependent Claim
1 words
6-fluorosucrose.
Claim 30
Dependent Claim
1 words
6-fluorosucrose.
Claim 31
Dependent Claim
1 words
6,1'-difluorosucrose.
Claim 32
Dependent Claim
1 words
6,1'-difluorosucrose.
Claim 33
Dependent Claim
1 words
6,6'-difluorosucrose.
Claim 34
Dependent Claim
1 words
6,6'-difluorosucrose.
Claim 35
Dependent Claim
1 words
6,1',6'-trifluorosucrose.
Claim 36
Dependent Claim
1 words
6,1',6'-trifluorosucrose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-14 | 1984-04-14 | 1984-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-14 | 1988-04-14 | 1988-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-14 | 1992-04-14 | 1992-10-14 | $7700.00 | Window Closed / Lapsed |