US4256875A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extraction of sennosides
Assignee: Synthelabo SA
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Filing: 1979-04-11
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Granted: 1981-03-17
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Expires: 1999-04-11
Abstract
Abstract A process for the extraction of sennosides from senna folioles and follicles, comprising the rapid exhaustion of the plant by means of cold water, in a neutral or slightly alkaline medium, followed by acidification and extraction with butanol. This process minimizes oxidation and hydrolysis of the product and achieves improved yields and purity.
Inventors
- 👤 Jean P. Gabriel
- 👤 Marcel Dumont
- 👤 Robert Guille
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 04:15
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/244; A; A61; A61K; A61K36/00; A61K36/18; A61K36/185; A61K36/48; A61K36/482
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
A process for the extraction of sennosides from senna folioles or follicles, comprising rapidly exhausting said senna folioles or follicles with cold water in a neutral or slightly alkaline medium, followed by acidification and extraction of the thus exhausted product with butanol.
Claim 2
Dependent Claim
42 words
A process for the extraction of sennosides from senna folioles or follicles, comprising rapidly exhausting said senna folioles or follicles with cold water in a neutral or slightly alkaline medium, followed by acidification and extraction of the thus exhausted product with butanol.
Claim 3
Dependent Claim
16 words
A process according to claim 1, wherein the water is rendered slightly alkaline with sodium bicarbonate.
Claim 4
Dependent Claim
19 words
A process according to claim 1 or 2, wherein the acidification is carried out by means of hydrochloric acid.
Claim 5
Dependent Claim
30 words
A process according to claim 1 or 2, wherein said senna folioles or follicles are washed with a solvent selected from ethanol, methylene chloride, hexane and benzene prior to exhausting.
Claim 6
Dependent Claim
28 words
A process according to claim 1 or 2, wherein said exhausted product which contains a large amount of sennosides is treated with ethyl acetate prior to said acidification.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-16 | 1984-09-15 | 1985-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-16 | 1988-09-15 | 1989-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-16 | 1992-09-15 | 1993-03-17 | $7700.00 | Window Closed / Lapsed |