US4288601A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluorination process
Assignee: Merck and Co Inc
•
Filing: 1979-09-19
•
Granted: 1981-09-08
•
Expires: 1999-09-19
Abstract
Abstract A process for preparing alpha -fluoromethyl amino acids is disclosed. The process utilizes SF4 and BF3 or AlCl3 in HF to effect the fluorination.
Inventors
- 👤 Janos Kollonitsch
- 👤 Stephen Marburg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 00:55
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
45 words
A process for preparing compounds having the formula ##STR6## wherein R is ##STR7## which comprises reacting a compound having the formula ##STR8## with (a) SF 4 and (b) BF 3 , in liquid HF at temperatures ranging from about -80° C. to about 20° C.
Claim 2
Dependent Claim
45 words
A process for preparing compounds having the formula ##STR6## wherein R is ##STR7## which comprises reacting a compound having the formula ##STR8## with (a) SF 4 and (b) BF 3 , in liquid HF at temperatures ranging from about -80° C. to about 20° C.
Claim 3
Dependent Claim
9 words
The process of claim 1 wherein R is ##STR9##
Claim 4
Dependent Claim
16 words
The process of claim 2 wherein said Formula I and II compounds have the S-isomer configuration.
Claim 5
Dependent Claim
15 words
The process of claim 1 wherein said temperature is -80° C. to about 0° C.
Claim 6
Dependent Claim
16 words
The process of claim 4 wherein said temperature is about -16° C. and R is ##STR10##
Claim 7
Dependent Claim
16 words
The process of claim 4 wherein said temperature is about -78° C. and R is ##STR11##
Claim 8
Dependent Claim
16 words
The process of claim 4 wherein said temperature is about -12° C. and R is ##STR12##
Claim 9
Dependent Claim
22 words
The process of claim 4 wherein said temperature is about -15° C. and R is H 2 N--(CH 2 ) 3 --.
References Cited (Backward Citations)
US3413326A
Cited
US4004996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-07 | 1985-03-09 | 1985-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-07 | 1989-03-09 | 1989-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-07 | 1993-03-09 | 1993-09-08 | $7700.00 | Window Closed / Lapsed |