US4294831A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purine derivatives
Assignee: SmithKline Beecham Corp
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Filing: 1978-02-01
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Granted: 1981-10-13
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Expires: 1998-02-01
Abstract
Abstract 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.
Inventors
- 👤 Howard J. Schaeffer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:04
CPC Classifications
A; A61; A61P; A61P31/00; A61P31/12; C; C07; C07C; C07C323/00; C07D; C07D473/00; C07D473/26; C07D473/32; C07D473/34
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
1 words
9-(2-propionyloxyethoxymethyl)guanine.
Claim 2
Dependent Claim
1 words
9-(2-propionyloxyethoxymethyl)guanine.
Claim 3
Dependent Claim
6 words
A pharmaceutically acceptable salt of 9-(2-propionyloxythoxymethyl)guanine.
Claim 4
Dependent Claim
6 words
A pharmaceutically acceptable salt of 9-(2-propionyloxythoxymethyl)guanine.
Claim 5
Dependent Claim
7 words
9-[2(2,2-Dimethylpropionyloxy)ethoxymethyl]guanine or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
7 words
9-[2(2,2-Dimethylpropionyloxy)ethoxymethyl]guanine or a pharmaceutically acceptable salt thereof.
Claim 7
Independent Claim
33 words
The method of treating a susceptible viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral nontoxic amount of 9-(2-propionyloxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof.
Claim 8
Independent Claim
33 words
The method of treating a susceptible viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral nontoxic amount of 9-(2-propionyloxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
23 words
A pharmaceutical composition comprising an effective antiviral amount of 9-(2-propionyloxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier therefore.
Claim 10
Dependent Claim
23 words
A pharmaceutical composition comprising an effective antiviral amount of 9-(2-propionyloxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier therefore.
Claim 11
Independent Claim
33 words
The method of treating a susceptible viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral nontoxic amount of 9-[2-(2-Dimethylpropionyloxyethoxymethyl]guanine or a pharmaceutically acceptable salt thereof.
Claim 12
Independent Claim
33 words
The method of treating a susceptible viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral nontoxic amount of 9-[2-(2-Dimethylpropionyloxyethoxymethyl]guanine or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
23 words
A pharmaceutical composition comprising an effective antiviral amount of 9-[2-(2,2-Dimethylpropionyloxyethoxymethyl]guanine or a pharmaceutically acceptable salt thereof together with a pharamaceutically acceptable carrier therefore.
Claim 14
Dependent Claim
23 words
A pharmaceutical composition comprising an effective antiviral amount of 9-[2-(2,2-Dimethylpropionyloxyethoxymethyl]guanine or a pharmaceutically acceptable salt thereof together with a pharamaceutically acceptable carrier therefore.
Claim 15
Dependent Claim
18 words
The method according to claim 4 in which the treated viral infection is caused by a herpes virus.
Claim 16
Dependent Claim
18 words
The method according to claim 6 in which the treated viral infection is caused by a herpes virus.
Claim 17
Dependent Claim
2 words
9-(2-acetyloxyethoxymethyl) guanine.
Claim 18
Dependent Claim
2 words
9-(2-acetyloxyethoxymethyl) guanine.
Claim 19
Dependent Claim
7 words
A pharmacuetically acceptable salt of 9-(2-acetyloxyethoxymethyl) guanine.
Claim 20
Dependent Claim
7 words
A pharmacuetically acceptable salt of 9-(2-acetyloxyethoxymethyl) guanine.
Claim 21
Dependent Claim
24 words
A pharmacuetical composition comprising an effective antiviral amount of 9-(2-acetyloxyethoxymethyl) guanine or a pharmacuetically acceptable salt thereof together with a pharmacuetically acceptable carrier therefore.
Claim 22
Dependent Claim
24 words
A pharmacuetical composition comprising an effective antiviral amount of 9-(2-acetyloxyethoxymethyl) guanine or a pharmacuetically acceptable salt thereof together with a pharmacuetically acceptable carrier therefore.
Claim 23
Independent Claim
35 words
The method of treating a susceptable viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral non toxic amount of 9-(2-acetyloxyethoxymethyl) guanine or a pharmacuetically acceptable salt thereof.
Claim 24
Independent Claim
35 words
The method of treating a susceptable viral infection in a mammal having said viral infection which comprises the administration of an effective antiviral non toxic amount of 9-(2-acetyloxyethoxymethyl) guanine or a pharmacuetically acceptable salt thereof.
Claim 25
Dependent Claim
15 words
The method of claim 13 in which the viral infection is a herpes virus infection.
References Cited (Backward Citations)
US4199574A
Cited
US4146715A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-12 | 1985-04-13 | 1985-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-12 | 1989-04-13 | 1989-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-12 | 1993-04-13 | 1993-10-13 | $7700.00 | Window Closed / Lapsed |