US4299826A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-acne composition
Assignee: Procter and Gamble Co
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Filing: 1979-10-12
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Granted: 1981-11-10
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Expires: 1999-10-12
Abstract
Abstract Compositions for topical application of erythromycin and derivatives of erythromycin, comprising an erythromycin compound and a member selected from the group consisting of lauryl alcohol, diisopropyl sebacate, dibutyl sebacate, dioctyl adipate, propylene glycol dipelargonate, ethyl laurate, butyl laurate, ethyl myristate, butyl myristate, isopropyl palmitate, oleyl alcohol, diethyl sebacate, dioctyl sebacate, dioctyl azelate, hexyl laurate, ethyl caprate, butyl stearate, isopropyl isostearate, 2-ethyl-hexyl pelargonate, butyl benzoate, benzyl benzoate, benzyl salicylate, and dibutyl phthalate, and mixtures thereof, are especially useful as a treatment for acne.
Inventors
- 👤 Wilmer L. Luedders
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/602; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00; A61Q; A61Q19/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
65 words
A composition for topical application to skin in the treatment of skin disorders and dermatoses of bacterial origin, comprising: (1) a minor proportion of an antibiotic agent selected from the group consisting of erythromycin and derivatives of erythromycin; and (2) a pharmaceutically-acceptable penetrating carrier comprising (a) a penetration enhancing amount of diisopropyl sebacate; and (b) the balance comprising a dermatologically acceptable alcohol, or mixture thereof.
Claim 2
Dependent Claim
65 words
A composition for topical application to skin in the treatment of skin disorders and dermatoses of bacterial origin, comprising: (1) a minor proportion of an antibiotic agent selected from the group consisting of erythromycin and derivatives of erythromycin; and (2) a pharmaceutically-acceptable penetrating carrier comprising (a) a penetration enhancing amount of diisopropyl sebacate; and (b) the balance comprising a dermatologically acceptable alcohol, or mixture thereof.
Claim 3
Dependent Claim
25 words
A composition according to claim 1 wherein the dermatologically acceptable alcohol is a member selected from the group consisting of ethanol, isopropanol, and mixtures thereof.
Claim 4
Dependent Claim
18 words
A composition according to claim 1 which comprises from about 0.1% to about 10% of the antibiotic agent.
Claim 5
Dependent Claim
12 words
A composition according to claim 2 wherein the antibiotic agent is erythromycin.
Claim 6
Dependent Claim
15 words
A composition according to claim 3 which comprises from about 2% to about 5% erythromycin.
Claim 7
Dependent Claim
17 words
A composition according to claim 2 wherein the antibiotic agent is an organic ester derivative of erythromycin.
Claim 8
Dependent Claim
17 words
A composition according to claim 6 wherein the organic ester derivative of erythromycin is erythromycin ethyl succinate.
Claim 9
Dependent Claim
25 words
A composition according to claim 3 wherein the derivative of erythromycin is selected from the group consisting of erythromycin propionate, erythromycin estolate, and erythromycin stearate.
Claim 10
Dependent Claim
21 words
A composition according to claim 5, comprising: (1) about 4% erythromycin; (2) about 30% diisopropyl sebacate; and (3) about 66% ethanol.
Claim 11
Dependent Claim
41 words
A method of topically treating skin disorders and dermatoses of bacterial origin in humans and lower animals in need of such treatment, comprising applying topically to the afflicted situs a safe and effective amount of a composition according to claim 1.
Claim 12
Dependent Claim
29 words
A method of treating acne by applying topically to the afflicted situs from about 0.1 mg./cm. 2 to about 25 mg./cm. 2 of a composition according to claim 1.
Claim 13
Dependent Claim
15 words
A method according to claim 10 or 11 in which the antibiotic agent is erythromycin.
Claim 14
Dependent Claim
16 words
A method according to claim 10 or 11 in which the antibiotic agent is erythromycin ethylsuccinate.
Claim 15
Dependent Claim
25 words
A method according to claim 13 in which the composition comprises: (1) about 4% erythromycin; (2) about 30% diisopropyl sebacate; and (3) about 66% ethanol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |