US4300569A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Red blood cell labelling kit
Assignee: Merck Sharp & Dohme (I.A.) Corp
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Filing: 1980-02-25
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Granted: 1981-11-17
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Expires: 2000-02-25
Abstract
Abstract This invention relates to a method for efficiently labelling red blood cells , which permits the imaging of blood pools in the intact animal or human patient, accomplished by injection of a saline solution of an alkaline earth metal salt of glucoheptonic acid and a non-toxic stannous salt followed by injection with a solution of sodium pertechnetate Tc 99 m to tag the red blood cells. The invention also relates to the kit used in the method of our invention consisting of a single vial containing 25 mg. calcium glucoheptonate and 3 mg. of stannous chloride dihydrate in 2 ml. of saline solution.
Inventors
- 👤 Paul-Emile Bonneau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:33
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0491; A61K51/12; A61K2123/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
65 words
A method of imaging blood pools in patients suspected of having cardiovascular abnormalities which comprises the steps of (1) intravenous injection of a solution comprising a water soluble, non-toxic, pharmaceutically acceptable salt of ketoglucoheptonic acid and a water soluble, non-toxic stannous salt; (2) waiting a period of 30 minutes; and (3) intravenous injection of a sterile saline solution containing from 2-20 mCi of sodium pertechnetate-Tc99m.
Claim 2
Independent Claim
65 words
A method of imaging blood pools in patients suspected of having cardiovascular abnormalities which comprises the steps of (1) intravenous injection of a solution comprising a water soluble, non-toxic, pharmaceutically acceptable salt of ketoglucoheptonic acid and a water soluble, non-toxic stannous salt; (2) waiting a period of 30 minutes; and (3) intravenous injection of a sterile saline solution containing from 2-20 mCi of sodium pertechnetate-Tc99m.
Claim 3
Dependent Claim
26 words
A method of imaging blood pools according to claim 1 wherein said glucoheptonate salt used is calcium glucoheptonate and said stannous salt is stannous chloride dihydrate.
Claim 4
Dependent Claim
34 words
A method of imaging blood pools according to claim 2 wherein the solution to be injected contains from 2.5-4 mg. of stannous salt, measured as stannous chloride dihydrate, and 25 mg. of calcium glucoheptonate.
Claim 5
Dependent Claim
33 words
A method of imaging blood pools according to claim 3 wherein the solution to be injected contains 3 mg. of stannous salt, measured as stannous chloride dihydrate, and 25 mg. of calcium glucoheptonate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |