US4301277A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
Assignee: SRI International Inc
•
Filing: 1980-10-20
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Granted: 1981-11-17
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Expires: 2000-10-20
Abstract
Abstract Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula <IMAGE> wherein R is COCH3 or -CHOHCH3 in the case of daunorubicin derivatives, or is -COCH2OH or -CHOHCH2OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.
Inventors
- 👤 Edward M. Acton
- 👤 Carol W. Mosher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:53
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
37 words
Compounds of the formula ##STR3## wherein R is selected from the group consisting of --COCH 3 , --CHOHCH 3 , --COCH 2 OH and --CHOHCH 2 OH and the pharmaceutically acceptable acid addition salts of said compounds.
Claim 2
Dependent Claim
37 words
Compounds of the formula ##STR3## wherein R is selected from the group consisting of --COCH 3 , --CHOHCH 3 , --COCH 2 OH and --CHOHCH 2 OH and the pharmaceutically acceptable acid addition salts of said compounds.
Claim 3
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-morpholinyl)daunorubicin and its pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
9 words
The compound of claim 2 which is 3'-deamino-3'-(4-morpholinyl)daunorubicin hydrobromide.
Claim 5
Dependent Claim
13 words
The compound of claim 1 which is 3'-deamino-3'-(4-morpholinyl)-13-dihydrodaunorubicin and its pharmaceutically acceptable salt.
Claim 6
Dependent Claim
9 words
The compound of claim 4 which is 3'-deamino-3'-(4-morpholinyl)-13-dihydrodoxorubicin hydrochloride.
Claim 7
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-morpholinyl)doxorubicin and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
15 words
The compound of claim 1 which is 3'-deamino-3'-(4-morpholinyl)-13-dihydrodoxorubicin and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
US4250303A
Cited
US4202967A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |