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US4302452A
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Use of derivatives of 6α-methylprednisolone as an antiemetic
Assignee: Pharmacia and Upjohn Co
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Filing: 1980-11-21
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Granted: 1981-11-24
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Expires: 2000-11-21
Abstract
Abstract Use of water soluble 21-polybasic esters of 1-dehydro-6α-methylhydrocortisone and their salts as an antiemetic.
Inventors
- 👤 Johnny M. Pittman, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
43 words
A method for the prevention of chemotherapeutic-induced nausea and vomiting which comprises administering intravenously to a patient expecting chemotherapy, a formulation comprising a compound selected from the group consisting of water soluble 21-dibasic esters of 1-dehydro-6α-methylhydrocortisone and their salts and a pharmaceutically-acceptable carrier.
Claim 2
Independent Claim
43 words
A method for the prevention of chemotherapeutic-induced nausea and vomiting which comprises administering intravenously to a patient expecting chemotherapy, a formulation comprising a compound selected from the group consisting of water soluble 21-dibasic esters of 1-dehydro-6α-methylhydrocortisone and their salts and a pharmaceutically-acceptable carrier.
Claim 3
Dependent Claim
14 words
A method according to claim 1 wherein the compound is 1-dehydro-6α-methylhydrocortisone 21-hemisuccinate sodium salt.
Claim 4
Dependent Claim
23 words
A method according to claim 1 or 2 wherein the amouint of compound administered is equivalent to 0.250 to 3 grams of 1-dehydro-6α-methylhydrocortisone.
Claim 5
Dependent Claim
37 words
A method according to claim 1 or 2 wherein the chemotherapeutic agent inducing the nausea and vomiting is Cis-Platinum and wherein the formulation is administered both prior to and subsequent to the administration of the chemotherapeutic agent.
References Cited (Backward Citations)
US2897218A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-23 | 1985-05-25 | 1985-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-23 | 1989-05-25 | 1989-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-23 | 1993-05-25 | 1993-11-24 | $7700.00 | Window Closed / Lapsed |